Dimethylformamide
Buy N,N-Dimethylformamide in ACS/AR, Lab, HPLC and Anhydrous Reagent Grade, in Stock Now.
Buy N,N-dimethylformamide online in the grade your synthesis or process calls for, with the price on the page and no quote to wait on. ACS/AR Grade and Lab Grade cover general synthesis, peptide coupling and polymer work. HPLC Grade is purified and tested for chromatography and analytical methods. Anhydrous Reagent Grade, held to 30 ppm water or less, is the one to reach for in moisture sensitive reactions, like those using sodium hydride or other reagents that react badly with water.
Every product ships with its SDS and COA posted online, and sizes run from 500 mL bottles up to 55 gallon drums. DMF is worth taking seriously before you order: it's flammable, it's classified as a reproductive toxicity hazard, and most SDS list it as a probable human carcinogen, so it ships to businesses, labs and schools, never residential addresses, and it's not certified Kosher, Halal or food grade on any of the four products here.
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Polar Organic Solvent Used In The Synthesis Of Organic Compounds
Dimethylformamide - 2 products All Filters
Dimethylformamide - 2 products About Dimethylformamide
C3H7NO. Picture formamide, then swap both of its hydrogens for methyl groups, and that's DMF. Pure material is a clear, nearly odorless liquid, though trace dimethylamine impurity is what gives some batches a faint fishy smell. It's miscible with water and most organic solvents, which along with its high boiling point (about 153°C) and low evaporation rate is exactly why it gets chosen for reactions and processes that run hot or need a solvent that won't flash off partway through. It also dissolves a wide range of both polar and nonpolar compounds, which is the other reason it shows up so often in polymer and fiber chemistry.
COMMON APPLICATIONS
Solvent for peptide coupling reactions in pharmaceutical synthesis, solid phase peptide synthesis, aldehyde and acyl halide synthesis, and the Heck reaction. Production of acrylic fibers, films and plastics. Manufacturing of adhesives and synthetic leathers. Extractive distillation for recovering olefins. Reagent and NMR spectroscopy reference standard. And, less happily, a solvent that shows up in some pesticide production processes.
GRADES EXPLAINED
ACS/AR Grade meets American Chemical Society reagent specifications, the one to reach for when a method names ACS or AR by name. Lab Grade is good working purity without that official monograph, a sensible lower cost choice for general synthesis and industrial use. HPLC Grade is purified and tested specifically to avoid ghost peaks and baseline noise in chromatography work. Anhydrous Reagent Grade takes water content down to 30 ppm or less, which matters for moisture sensitive chemistry where even a small amount of water can quench a reaction or ruin a yield.
TYPES & GRADES AT A GLANCE
Meets ACS reagent specifications, for methods that call for it by name.
Solid everyday purity at a lower price, for general synthesis and industrial use.
Purified and tested for chromatography and analytical methods.
Low water content DMF for moisture sensitive reactions.
WHY BUY FROM LAB ALLEY
256,000+ customers already order their solvents and chemicals from Lab Alley. 99.5% of orders ship within 1 to 2 business days, and 98.9% inventory accuracy means the grade you see in stock is the grade that ships. SDS and COA are available online for every DMF product. None of the dimethylformamide products on this page carry Kosher, Halal or food grade certification.
Related: See our Acetonitrile collection, or browse all Solvents.
Frequently Asked Questions
Where can I buy DMF online?
Right here. We carry dimethylformamide in ACS/AR, Lab, HPLC and Anhydrous Reagent Grade, from 500 mL bottles up to 55 gallon drums. Pick the grade and size, check the price, and order with no quote needed for standard sizes. Most in stock orders ship within 1 to 2 business days.
Is DMF dangerous to work with?
It needs real respect, yes. DMF is a flammable liquid, and most SDS classify it as reproductive toxicity category 1B and list it as a probable human carcinogen, with the liver as the main organ of concern on repeated exposure. It also absorbs through skin, so proper gloves, eye protection and fume hood ventilation aren't optional. Review the SDS fully before handling it, and never work with it outside a controlled lab or industrial setting.
ACS/AR Grade or Lab Grade, which DMF do I actually need?
If your method or SOP names ACS or AR by name, or you're doing analytical work where impurity limits matter, go with ACS/AR Grade. If you're running general synthesis, polymer work or industrial processing where that certified purity profile isn't required, Lab Grade does the job at a lower price. Both are 99.8% assay; the real difference is the documented, tested impurity specification behind the ACS grade.
What's different about HPLC Grade versus Anhydrous Grade?
They solve two different problems. HPLC Grade is purified and tested to avoid trace impurities that would show up as noise or ghost peaks in a chromatography run. Anhydrous Reagent Grade is tested for water content instead, held to 30 ppm or less, which matters when you're running a reaction that water would interfere with or outright ruin, regardless of whether chromatography is involved at all.
Is any of your DMF Kosher, Halal or food grade?
No. None of the four dimethylformamide products on this page carry Kosher, Halal or food grade certification. They're sold strictly for laboratory, analytical and industrial use. Each product does have an SDS and lot specific COA on its page, so you can confirm the exact specs before ordering.
Do I need a permit, and can DMF ship to a home address?
No purchase permit is required. DMF does ship as a DOT regulated flammable liquid (UN2265, Class 3, Packing Group III), so it's restricted to business, lab or school delivery addresses rather than residential ones. Each product page lists its specific shipping details, and Customer Care at 512-668-9918 can confirm before you order if you're not sure your address qualifies.
What is DMF actually used for?
Mostly synthesis and manufacturing work. It's the standard solvent for peptide coupling reactions in pharma, solid phase peptide synthesis, and reactions like the Heck reaction and aldehyde synthesis. On the manufacturing side, it's used to produce acrylic fibers, films, plastics, adhesives and synthetic leathers, and it shows up as a reagent and NMR reference standard. Given its toxicity profile, every application should go through a proper risk assessment first.
Can I buy DMF in bulk?
Yes. Lab Grade and ACS/AR Grade both scale up through 5 gallon pails and 55 gallon drums right on the product page. For pallets or a recurring delivery schedule, request pricing through Bulk & Custom Chemicals. Autoship takes 10% off eligible repeat orders.
How should DMF be stored?
Keep it tightly sealed in its original container, in a cool, dry, well ventilated area locked away from general access, since it's both flammable and a serious health hazard. Store it away from strong acids, strong bases and oxidizers, since DMF can break down into formic acid and dimethylamine under those conditions. The Chemical Storage Compatibility Chart is worth checking before storing it near other reactive chemicals.
Industries That Use Dimethylformamide
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