NMP, 1-Methyl-2-Pyrrolidone, ACS Grade

N-Methyl-2-Pyrrolidone (NMP) is a polar aprotic, low viscosity liquid with a high boiling point. NMP has strong organic/inorganic compound solvency, is miscible with water at all temperatures, and has excellent chemical and thermal stability. It is a colorless liquid, although impure samples can appear yellow. Due to its polar nature and low surface tension, it is widely employed as a cleaning agent. Our premium quality N-Methyl-2-Pyrrolidone (NMP), ACS Grade, 99.5% is certified by the American Chemical Society (ACS) and is highly recommended for getting consistent and repetitive results in research/biochemical labs. Furthermore, it can be used in food items and medicines due to its high purity.

About NMP (N-Methyl-2-Pyrrolidone) Solvent And NMP Chemical Properties

• NMP CAS Registry Number: 872-50-4
• 1-Methyl-2-pyrrolidinone CID: 13387
• NMP NFPA 704 (fire diamond)‎: ‎2 2 1
• NMP Log P‎: ‎−0.40
• NMP Boiling point: 395.6°F (202°C)
• NMP Density: 1.03 g/cm³
• NMP Formula: C5H9NO
• NMP Solubility In Water: Soluble
• How N-Methyl-2-pyrrolidone Is Shipped In The USA: Lab Alley Ships NMP By UPS And FedEx
• NMP Molar Mass: 99.133 g·mol−1
• NMP Melting Point: −24 °C (−11 °F; 249 K)
• N-Methylpyrrolidone Structure, Properties, Spectra, Suppliers And Links
• N-Methylpyrrolidone ChemSpider ID: 12814
• 1-Methyl-2-pyrrolidinone PubChem CID: 13387
• 1-Methyl-2-pyrrolidinone Safety And Hazards
• Preferred IUPAC name: 1-Methylpyrrolidin-2-one
• Other Names For N-Methyl-2-Pyrrolidone: NMP, 1-Methyl-2-pyrrolidone, N-Methylpyrrolidone, N-Methylpyrrolidinone, Pharmasolve
• NMP Miscibility Chart
• NMP Vapor Density‎: ‎3.4 (vs air)
• NMP Refractive Index‎: ‎n20/D 1.47 (lit.)
• NMP Toxicity
• NMP SDS: Contact Lab Alley At 512-668-9918 For An NMP Safety Data Sheet 
• NMP Chemical Compatibility
• NMP NMR (Nuclear Magnetic Resonance)
• N-Methyl Pyrrolidone Rice Cooker: N-Methyl Pyrrolidone is used as a nonstick coating on the inner cooking pans of rice cookers. 
• NMP Solvent pKa: Strongest Basic

NMP Uses

• HPLC And TLC Solvent
• NMP (N-Methyl-2-Pyrrolidone) is a polar solvent with outstanding characteristics. It has a wide range of applications because it offers very high solvency, high boiling point, low freezing point, and ease of handling. Read more here.
• Preparation of 2-aryl and 2-alkyl benzothiazoles
• Extraction Of Aromatics
• Ullmann coupling reaction of aryl halides and phenols to form Ullmann ethers in the presence of 2,2,6,6-tetramethylheptane-3,5-dione
• NMP is used in the extraction of aromatic compounds from alkane−aromatic mixtures.
• Stille cross-coupling reaction of aryl iodides with organostannanes catalyzed by Pd/C in the presence of copper iodide as cocatalyst.

Is NMP Toxic?

N-methyl-2-pyrrolidone (NMP) is a common solvent with low acute toxicity and no genotoxic or carcinogenic effects but is teratogenic at high exposures (Akesson, 2001, Saillenfait et al., 2007). Read more here.

What Is NMP Used For?

N-Methylpyrrolidone (NMP) is a water-miscible organic solvent. NMP is widely used in the petrochemical industry, and in the manufacturing of various compounds, including pigments, cosmetics, insecticides, herbicides, and fungicides. NMP increasingly is used as a substitute for chlorinated hydrocarbons. Read more here.

Solvent Users Look To Replace NMP 

Once touted as benign, the solvent N-methyl-2-pyrrolidone (NMP) is under scrutiny because of concerns over its potential health effects. Read more here.

Is NMP Flammable?

N-Methyl-Pyrrolidone is a clear, colorless liquid with a boiling point of 204 °C and a melting/freezing point of -24.2 °C. NMP is non-explosive but is a combustible liquid with its flammability derived from its flash point of 91°C. NMP has a self-ignition temperature of 245 °C. Read more here.

NMP Solvent Viscosity

N-Methyl-2-Pyrrolidone (NMP) is a high boiling, polar aprotic, low viscosity liquid. NMP has a good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability. Read more here.

Is NMP Soluble In Water?

N-Methyl-2-Pyrrolidone (NMP) is a high boiling, polar aprotic, low viscosity liquid. NMP has a good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability. Read more here.

Is NMP Carcinogenic?

The substance is listed as a carcinogen and reproductive toxicant under Proposition 65. This past autumn, the Halogenated Solvents Industry Alliance petitioned the Consumer Products Safety Commission (CPSC) to expand its existing labelling policy to address acute hazards from inhalation of the substance. Read more here.

Is N-Methyl-2-pyrrolidone Corrosive?

N-Methyl-2-pyrrolidone (NMP) (CAS No. 872-50-4) is a water-miscible organic solvent. It is a hygroscopic colourless liquid with a mild amine odour. NMP is not degraded by chemical hydrolysis. Read more here.

N-Methyl-2-Pyrrolidone Product Description 

N-Methyl-2-Pyrrolidone (NMP) is a high boiling, polar aprotic, low viscosity liquid. NMP has a good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability. It is used as a solvent for engineering polymers and coating resins. Additionally, the polar nature and the low surface tension of NMP makes it an excellent cleaning medium and paint stripping solvent. NMP is a powerful solvent with a low volatility used for a wide range of chemicals and finds its application among others in petrochemical processing. NMP is used as extraction medium in several industrial processes because of its affinity for unsaturated hydrocarbons and aromatics, for example butadiene recovery, BTX extraction and lube oil purification. NMP is used in electronics, as photoresist stripper, for defluxing, degreasing and cleaning. NMP is a solvent for the production of FCCL, olyamide/polyimide wire enamels, epoxy and polyurethane coatings. NMP is used in pharmaceuticals and as a solvent and extraction medium. NMP is used for industrial and household cleaning, paint stripping, in graffiti removers, oven cleaners, in automotive and industrial cleaner formulations. NMP is used for agrochemicals, as a solvent during synthesis or as a formulation agent.

NMP Toxicity

N-methyl-2-pyrrolidone (NMP) is a common solvent with low acute toxicity and no genotoxic or carcinogenic effects but is teratogenic at high exposures (Akesson, 2001, Saillenfait et al., 2007). Considered inert, NMP is used in applications with human exposure at high levels (Table S1) (Jouyban et al., 2010). Read more here.

Method For Purifying N-methyl-2-pyrrolidone

Traces of amine impurities can remain in the NMP even after thorough distillation. Moreover, NMP can develop undesirable color upon prolonged storage, particularly if the solvent contains traces of acids, amines, or other impurities. Read more here.

NMP Solvent Battery

NMP is also used heavily in lithium ion battery fabrication, as a solvent for electrode preparation, though there is much effort to replace it with solvents of less environmental concern, like water. Read more here. 

For NMP, it is used as a solvent for electrolytes in aluminum capacitors for lithium ion batteries and also as a solvent to solubilize polyvinylidene flouride for lithium polymer batteries. Typically EG and Ultra 2 grades of NMP are used for this market/application. It is used because of its high flashpoint, high solvency and low toxicity, it is water soluble with high electrical conductivity. Read more here.

Commercial Li-ion battery electrodes are manufactured by casting a slurry onto a metallic current collector. The slurry contains active material, conductive carbon, and binder in a solvent. The binder, most commonly polyvinylidene fluoride (PVDF), are pre-dissolved in the solvent, most commonly N-Methyl-2-pyrrolidone (NMP). During mixing, the polymer binder flows around and coat the active material and carbon particles. After uniformly mixing, the resulting slurry is cast onto the current collector and must be dried. Evaporating the solvent to create a dry porous electrode is needed to fabricate the battery. Drying can take a wide range of time with some electrodes taking 12–24 hours at 120 °C to completely dry. In commercial applications, an NMP recovery system must be in place during the drying process to recover evaporated NMP due to the high cost and potential pollution of NMP. While the recovery system makes the entire process more economical it does require a large capital investment. Less expensive and environmentally friendly solvents, such as aqueous based slurries, could eliminate the large capital cost of the recovery system but the electrode would still require a time and energy demanding drying step. Uncoventional manufacturing methods have also been used to create battery electrodes. Solvent based electrostatic spray deposition has been used to coat current collectors with electrode material. This is achieved by adding high voltage to the deposition nozzle and grounding the current collector, which causes the deposition material to become atomized at the nozzle and drawn to the current collector. Electrodes constructed with this method exhibit similar characteristics as slurry-cast electrodes and have similar disadvantages in that they also require a time and energy intesive drying process (2 hours at 400 °C). Lithium ion batteries have also been manufactured using spray painting techniques by using NMP based paints to spray each electrode component onto the desired surface. While this allows for battery fabrication on a variety of surfaces it still requires the solvent to be evoporated. Read more here.

N-Methyl-2 Pyrrolidone (NMP) Uses

NMP is a very versatile solvent with a wide range of uses. It a powerful compound that is considered reliable due to its high thermal and chemical stability. In spite of its use in a number of chemical products, NMP is biodegradable and recyclable (via distillation). NMP can be used for coating, cleaning and stripping. Some of its applications include:

• Photoresist stripping for electronics
• Stripping agent for various consumer and industrial products
• Cost-effective solution for graffiti removal; highly effective in removing crayon and lipstick from various surfaces
• Solvent for use in pharmaceutical formulations; may be a good compound to use as an enhancer for more effective skin penetration of cosmetics and medicines
• Solvent for mixing and producing various formulations for use in agriculture
• The compound is usually a clear to a very light yellow liquid. It can be combined with commonly used solvents including chloroform, benzene, certain ketones or alcohols, and ethyl acetate. It has a high boiling temperature, a low volatility and a high flashpoint. Read more here.

Information On 1-Methyl-2-pyrrolidinone From PubChem

N-methyl-2-pyrrolidone appears as a clear colorless liquid with a "fishlike" odor. Denser than water. Flash point 199°F. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion. N-methylpyrrolidin-2-one is a member of the class of pyrrolidine-2-ones that is pyrrolidin-2-one in which the hydrogen attached to the nitrogen is replaced by a methyl group. It has a role as a polar aprotic solvent. It is a N-alkylpyrrolidine, a lactam and a member of pyrrolidin-2-ones. Solvent for resins, acetylene, etc., pigment dispersant, petroleum processing, spinning agent for polyvinyl chloride, microelectronics industry plastic solvent applications, intermediate. SOLVENT FOR CARBON DIOXIDE REMOVAL IN AMMONIA GENERATORS, POLYMER PREPN, & PROCESSING ACETYLENE; SOLVENT FOR EXTRACTION OF BTX AROMATICS & BUTADIENE. Pharmaceutical applications make use of the properties of 1-methyl-2-pyrrolidone as a penetration enhancer for a more rapid transfer of substances through the skin. ... Approved as a solvent for slimicide application to food packaging materials. Used in the extraction of unsaturated/aromatic compounds, the purification of acetylenes, olefins, and diolefins, gas purification, and aromatic extraction from feedstocks. 1-Methyl-2-pyrrolidinone is a possible substitute for methylene chloride for use in paint stripper formulations. Read more here.

Information On N-Methyl-2-pyrrolidone From Wikipedia

N-Methyl-2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam. It is a colorless liquid, although impure samples can appear yellow. It is miscible with water and with most common organic solvents. It also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide. It is used in the petrochemical and plastics industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials.

NMP is produced industrially by a typical ester-to-amide conversion, by treating butyrolactone with methylamine. Alternative routes include the partial hydrogenation of N-methylsuccinimide and the reaction of acrylonitrile with methylamine followed by hydrolysis. About 20,000 to 30,000 tons are produced annually.

NMP is used to recover certain hydrocarbons generated in the processing of petrochemicals, such as the recovery of 1,3-butadiene and acetylene. It is used to absorb hydrogen sulfide from sour gas and hydrodesulfurization facilities. Its good solvency properties have led to NMP's use to dissolve a wide range of polymers. Specifically, it is used as a solvent for surface treatment of textiles, resins, and metal coated plastics or as a paint stripper. It is also used as a solvent in the commercial preparation of polyphenylene sulfide. In the pharmaceutical industry, N-methyl-2-pyrrolidone is used in the formulation for drugs by both oral and transdermal delivery routes. It is also used heavily in lithium ion battery fabrication, as a solvent for electrode preparation, though there is much effort to replace it with solvents of less environmental concern, like water.

In rats, NMP is absorbed rapidly after inhalation, oral, and dermal administration, distributed throughout the organism, and eliminated mainly by hydroxylation to polar compounds, which are excreted via urine. About 80% of the administered dose is excreted as NMP and NMP metabolites within 24 hours. A probably dose dependent yellow coloration of the urine in rodents is observed. The major metabolite is 5-hydroxy-N-methyl-2-pyrrolidone. Studies in humans show comparable results. Dermal penetration through human skin has been shown to be very rapid. NMP is rapidly biotransformed by hydroxylation to 5-hydroxy-N-methyl-2-pyrrolidone, which is further oxidized to N-methylsuccinimide; this intermediate is further hydroxylated to 2-hydroxy-N-methylsuccinimide. These metabolites are all colourless. The excreted amounts of NMP metabolites in the urine after inhalation or oral intake represented about 100% and 65% of the administered doses, respectively. NMP has a low potential for skin irritation and a moderate potential for eye irritation in rabbits. Repeated daily doses of 450 mg/kg body weight administered to the skin caused painful and severe haemorrhage and eschar formation in rabbits. These adverse effects have not been seen in workers occupationally exposed to pure NMP, but they have been observed after dermal exposure to NMP used in cleaning processes. No sensitization potential has been observed. Read more here.

N-Methyl-2-Pyrrolidone (NMP), ACS Grade, 99.5% Features:

• Reagent
• Solvent
• Cleaning agent

• Petrochemicals
• Cosmetics
• Synthesis of insecticides
• Polymer industry

If you have questions about ordering N-Methyl-2-Pyrrolidone (NMP) online here at LabAlley.com or would like to place an order, call 512-668-9918 or email customerservice@laballey.com to talk with an NMP Specialist. 

Please contact us to request a Safety Data Sheet (SDS) and Certificate of Analysis (COA) for 1-Methyl-2-Pyrrolidinone ACS.