Methanol 99% HPLC Grade

Specifically Manufactured For Use In High-Performance Liquid Chromatography


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About Methanol 99% HPLC Grade

A high-purity form of methanol that is specifically manufactured and purified for use in high-performance liquid chromatography (HPLC) and other analytical techniques. In HPLC, the choice of solvent is critical because any impurities in the solvent can interfere with the separation and detection of compounds in the sample. Impurities can lead to baseline noise, inaccurate peak detection, and altered retention times. Therefore, using solvents of high analytical grade, such as Methanol 99% HPLC Grade, helps ensure that the analytical results are reliable and consistent.

Common Uses and Applications

  • HPLC Analysis: Methanol is widely used as a solvent in high-performance liquid chromatography (HPLC) for the separation, identification, and quantification of compounds in complex mixtures. Its high purity ensures minimal interference with the separation process and accurate detection of analytes.

  • Sample Preparation: Methanol is often used for preparing samples for various analytical techniques, including HPLC. It's used to dissolve and dilute samples, ensuring that the analytes are in a suitable form for analysis.

  • Spectroscopy: Methanol can be used as a solvent for preparing samples for spectroscopic techniques such as UV-Vis spectroscopy, NMR (nuclear magnetic resonance) spectroscopy, and IR (infrared) spectroscopy.

  • Standard Preparation: High-purity methanol is essential for preparing accurate and reliable calibration standards for analytical instruments. This is crucial for ensuring the precision and accuracy of analytical results.

  • Liquid Chromatography-Mass Spectrometry (LC-MS): Methanol can be used as a solvent in LC-MS analyses, where liquid chromatography is coupled with mass spectrometry for the identification and quantification of compounds in complex samples.

  • Solvent for Reagents: Methanol can be used as a solvent for various reagents and chemicals used in laboratory experiments, where the purity of the solvent is critical to obtaining accurate results.

  • Extraction of Compounds: Methanol is used for extracting compounds from solid samples, plant materials, or other matrices, particularly in procedures like Soxhlet extraction or maceration.

  • Cleaning and Degreasing: In addition to its analytical applications, methanol can be used for cleaning and degreasing laboratory equipment due to its solvent properties.


Chemistry Table

Methyl alcohol, Wood alcohol, Carbinol, Wood spirit, Wood naphtha, Methylol, Methyl hydroxide, Pyroxylic spirit
HPLC Grade
Min 99.9 %

Methanol 99% HPLC Grade Specifications

Assay (by GC-FID) (Corrected for Water) Min 99.9 %
Description Clear colorless liquid free of
suspended matter
Acetaldehyde Max 0.001 %
Acetone Max 0.001 %
Color Max 10 APHA
Formaldehyde Max 0.001 %
Residue after Evaporation Max 5 ppm
Solubility in Water Passes Test
Substances Darkened by Sulfuric acid Passes Test
Substances Reducing Permanganate Passes Test
Titrable Acid Max 0.0003 meq/g
Titrable Base Max 0.0002 meq/g
Water (by KF coulometry) Max 0.10 %
Optical Absorbance at
205 nm
220 nm
240 nm
250 nm
280 nm
400 nm

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Safety and Shipping Information

Methanol, HPLC Grade Shipping Information:
DOT: Methanol, 3, UN1230, PG II

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