Quinine Sulfate | Antiviral Chemical Compound | QS | For Antimalarial Uses | Quinine Hydrogen Sulfate
- Quinine sulfate (Quinine Hydrogen Sulfate) is a organic sulfate salt obtained from guanethidine and sulfuric acid in a 2:1 ratio. It has a role as an antimalarial. It contains a quinine and a quinine(1+).
- Chloroquine is a semisynthetic derivative of quinine.
- Currently in 2020, the synthetic form of quinine, Chloroquine is being researched and studied to see if it can effectively treat infectious diseases.
- FDA approved drugs such as quinine sulfate inhibit Dengue virus (DENV) replication.
- Quinine Sulfate (QS) significantly inhibits the internalization/invasion efficacy of E. coli in the host cells.
- Quinine has been shown to have inherent antibacterial and antifungal properties at high concentrations.
- Quinine was first isolated in 1820 from the bark of a cinchona tree.
- Quinine sulfate is on the World Health Organization's List of Essential Medicines and is classified as one of the safest and most effective medicines needed in healthcare facilities.
- Quinine treats malaria, babesiosis and other parasitic diseases. Parasites disappear from the blood stream with quinine treatment. Quinine does not kill parasites living outside the red blood cells.
- Chloroquine analogues have been found to be effective against bacterial infections such as endocarditis and Q fever, parasitic infections such as giardiasis and viral infections such as Ebola virus disease, hepatitis C virus-related arthritis and chikungunya.
Quinine Sulfate is the sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. Quinine sulfate is a organic sulfate salt obtained from guanethidine and sulfuric acid in a 2:1 ratio. It has a role as an antimalarial. It contains a quinine and a quinine(1+). Read more here.
Quinine is prescribed to treat malaria in people who have been bitten by an infected mosquito. It is not suitable for preventing malaria. Quinine is an ingredient of drinks such as tonic water and bitter lemon - try to avoid these while you are taking quinine tablets. Contact a doctor immediately if anyone swallows quinine by accident, or if you take more than the prescribed dose. Read more here.
About Quinine, Hydroxychloroquine And Chloroquine
Quinine Sulfate is antiviral and is used as an antimalarial drug. Quinine is used to treat malaria, as it kills the parasites living in red blood cells. The synthetic form of quinine, chloroquine, used to treat malaria, may have some properties that fight viruses and scientists are calling for more work to investigate. Hydroxychloroquine is a common derivative of chloroquine. Quinine and quinine derivatives have been used for two hundred years, and the bark from which it is extracted for far longer. Their safe usage and potential side effects are well established. It is little surprise then that plant products and their analogues have been employed as an early line of defense against viruses. Buy virus disinfectants online here.
Quinine sulfate is commercially available in 324-mg tablets under the brand name Qualaquin. Quinine is also used to treat lupus and arthritis. Quinine sulfate at a dose of 200–300 mg at night has been used for many years to treat nocturnal leg cramps but the FDA warns against this type of usage.
Quinine Sulfate is the sulfate salt form of the quinidine alkaloid isolate quinine. Quinine is a medication used to treat malaria and babesiosis. This includes the treatment of malaria due to Plasmodium falciparum that is resistant to chloroquine when artesunate is not available. Chloroquine is a synthetic form of quinine.
Recently, quinine sulfate was tested in vitro against emerging dengue virus (DENV) strains in different cell lines, showing a reduction in DENV-2 virion production up to 80% compared to that of the untreated control and a concentration-dependent reduction in DENV RNA and viral proteins.
- PubChem CID: 16051948
- Quinine Sulfate Molecular Formula: C40H50N4O8S
- Quinine Sulfate Molecular Weight: 746.9 g/mol
- Quinine Sulfate ChemSpider ID: 10124000
- Quinine Sulfate Structure, Properties, Spectra, Suppliers And Links
- Quinine Sulfate Indications
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- Quinine Sulfate Safety And Hazards
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Federal law expressly prohibits the sale of over-the-counter quinine sulfate products. 21 C.F.R. Sections 310.546 & 310.547. Effective February 13, 2007, the Food & Drug Administration (“FDA”) ordered all manufacturers of prescription quinine sulfate products not approved for marketing by FDA to cease manufacturing. Read more here.
Quinine Sulfate (QS) Reduces Herpes Virus Type I (HSV-1) Replication
Although antimalarial drugs have been developed primarily to treat malaria, they are also beneficial for many dermatological, immunological, and rheumatological diseases, for which they are mostly used today in the Western world. The aim of the present study was to investigate the effect of quinine sulfate (QS) on the multiplication and adsorption of herpes virus type I (HSV-1). When Vero cells (African green monkey kidney) are infected with HSV-1 in the presence of QS, the viral adsorption is reduced, as demonstrated by a decrease of the number of microscopic plaques of the virus. When the virus-infected Vero cells are incubated in the presence of QS, the multiplication of HSV-1 is also reduced, and the diameter of the plaque are visibly smaller. The practical implications of the antiviral action of antimalarial drugs might be especially important to immunosuppressed patients who receive these drugs for autoimmune collagen-vascular diseases or as additional therapy for AIDS.
Some products that may interact with this drug include: "blood thinners" (such as warfarin), penicillamine. ... Because cimetidine and aluminum/magnesium antacids may interact with quinine, ask your pharmacist about other products to treat extra stomach acid. Quinine is very similar to quinidine. Read more here.
Quinine is a medication used to treat malaria and babesiosis. This includes the treatment of malaria due to Plasmodium falciparum that is resistant to chloroquine when artesunate is not available. While used for restless legs syndrome, it is not recommended for this purpose due to the risk of side effects. It can be taken by mouth or used intravenously. Malaria resistance to quinine occurs in certain areas of the world. Quinine is also the ingredient in tonic water that gives it its bitter taste. Quinine is an alkaloid, a naturally occurring chemical compound. How it works as a medicine is not entirely clear. Quinine was first isolated in 1820 from the bark of a cinchona tree. Bark extracts have been used to treat malaria since at least 1632. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. Read more here.
Quinine Sulfate O.R. Features:
|Assay [(C20H24N2O2)2-H2SO4;Anhydrous Basi||99.0-101.0%|
|Specific Rotation @ 25°C||-235° to -245°|
|Chromatographic Purity||To Pass Test|
|Residue on Ignition||0.1%|
|Chloroform- Alchohol-Insoluble Substances||0.1%|
|Organic Volatile Impurities||To Pass Test|
Please contact us to request a Safety Data Sheet (SDS) and Certificate of Analysis (COA) for Quinine Sulfate O.R.
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