Benzalkonium Chloride, USP/NF Grade, 50%

Benzalkonium Chloride 50% Concentrate For Sale In Bulk Online At LabAlley.com

 

Benzalkonium Chloride Chemical Properties

Using Benzalkonium Chloride To Make Hand Sanitizers

Benzalkonium chloride, along with both ethanol and isopropanol, are deemed eligible by the FDA for use in the formulation of healthcare personnel hand rubs although available evidence indicates benzalkonium chloride has less reliable activity against viruses than either of the alcohols.

Use Benzalkonium Chloride To Deactivate Viruses

Benzalkonium chloride (as Roccal or Zephiran) was found to inactivate influenza, measles, canine distemper, rabies, fowl laryngotracheitis, vaccinia, Semliki Forest, feline pneumonitis, meningopneumonitis, and herpes simplex viruses after 10 minutes of exposure at 30 C or at room temperature. Read more here. 

Type A influenza viIrus was inactivated by concentrations of benzalkoniunm chloride as low as 0.025 mng/iml. Measles and canine distemper viruses were also sensitive to the quaternary. Feline pneuiinonitis and miieningopneumionitis agents were inactivated by benzalkonium chloride after 10 minutes of exposure at room temperature. Rabies, fowl laryngotracheitis, Seliliki Forest, and herpes simplex viruses were rapidly inactivated by low concentrations of benzalkonium chloride. Review more information on the virucidal activity of benzalkonium chloride for 13 viruses here.

Is Benzethonium Chloride (BZK) An Antiviral? 

Yes, BZK is known to be effective in killing enveloped viruses and demonstrates concentration-dependent antiviral activity against adenovirus in vitro. This quaternary ammonium compound has also been shown to kill norovirus, influenza, herpes simplex viruses type 1 and human immunodeficiency virus type 1, but is ineffective in inactivating enveloped, and the non-enveloped viruses. The U.S. Centers for Disease Control and Prevention state that hand sanitizers that contain Benzalkonium Chloride are less reliable for tackling viruses than those which are alcohol-based.

How To Dilute Benzalkonium Chloride

Benzalkonium Chloride Disinfectant Dilution: 
Benzalkonium chloride is a frequently used preservative in eye drops; typical concentrations range from 0.004% to 0.01%. Stronger concentrations can be caustic and cause irreversible damage to the corneal endothelium. Benzalkonium chloride formulations for consumer use are dilute solutions. Read more here. 

Benzalkonium chloride 0.13% v/v solution is used in BZK Antiseptic Towelettes which are used in first aid to help prevent skin infection in minor cuts, scrapes, and burns. Get more information on benzalkonium chloride 0.13 here. Benzalkonium Chloride 50% solution purchased online at LabAlley.com is diluted to make alcohol-free hand sanitizers.

Use Benzalkonium Chloride To Make BZK Antiseptic Towelettes

BZK antiseptic towelettes are alcohol-free antiseptic wipes that do not sting. Buy BZK 50% solution online at LabAlley.com to make your own all-purpose antibacterial sanitizing wipes.  Buy alternative ingredients to alcohol to make antibacterial hand wipes and antiseptic creams online here. Hospitals and doctor's offices order fast-acting benzalkonium chloride at LabAlley.com to make sterile cleaning wipes for clean catch urine collection and to prevent infections caused by burns, scrapes and cuts.  Benzalkonium Chloride is an antimicrobial agent that works by killing microorganisms and inhibiting their future growth.

Because BZK is a biocide, BZK antiseptic towelettes are active against viruses and bacteria. Make your own BZK towelettes to use for minor wound care and postpartum perineal care. Buy BZK at LabAlley.com to make antiseptic cleaning products. Medical supply companies like Dynarex Corporation make medicated wipes and towelettes using antiseptic benzalkonium chloride solutions.  Fragrance free and alcohol free single-use medical-grade wipes such as Dynarex BZK Antiseptic Towelettes and Dynarex 1303 BZK Antiseptic Towelettes, are used to prevent infection and for cleansing and refreshing.

Because of the antimicrobial activity of BZK, the Benzalkonium Chloride 50% Solution sold online at LabAlley.com is used to make DIY disinfectant wipes and consumer products such as ear, eye and nasal drops or sprays. Cosmetic makers in the U.S. buy BZK from LabAlley.com to manufacture deodorants, soaps, wet wipes, shampoos and hand sanitizers.  

Quaternary ammonium compounds and disinfectants purchased at wholesale prices from Lab Alley are used throughout the United States to make wound wash sprays and spermicidal creams, as well as single-application treatments for fever blisters, cold sores and herpes. BZK 50% solution can be diluted to make spray disinfectants for hard surface sanitization. Antiseptic makers buy benzalkonium chloride, ethanol and hydrogen peroxide in bulk quantities online at LabAlley.com.

Because BZK (alkyl dimethyl benzyl ammonium chloride) is an organic salt classified as a quaternary ammonium compound and not an alcohol, it does not cause a burning sensation when applied to broken skin. BZK antiseptic towelettes have widespread applications due to the wide spectrum antimicrobial properties of benzalkonium chloride against bacteria, fungi, and viruses. Benzalkonium chloride ordered online at LabAlley.com is used to make antibacterial surface cleanser wipes.

Is Benzalkonium Chloride Safe For Skin?

Benzalkonium Chloride is a commonly used preservative in contact lens solutions and can be found as an ingredient in antimicrobial soaps, skin antiseptics, and spermicides. Safety Information: It was concluded that Benzalkonium Chloride can be safely used as antimicrobial agent at concentrations up to 0.1%. Read more here.

What Is The Antibacterial Effect Of Benzalkonium Chloride?

Benzalkonium chloride (BAC) is a wide spectrum quaternary ammonium antibacterial agent that has been used in various dental composites. It is cationically charged and induces antibacterial action through attraction to the negatively charged bacterial membrane. Read more here.

Is Benzalkonium Chloride An Antifungal?

The benzalkonium chloride was found to be active against all fungal species but to a different extent. Addition of ethylenediamine-tetraacetic acid and its sodium salt increased the sensitivity of fungi to benzalkonium chloride. Read more here.

Is Benzalkonium Chloride Toxic?

Benzalkonium chloride formulations for consumer use are dilute solutions. Concentrated solutions are toxic to humans, causing corrosion/irritation to the skin and mucosa, and death if taken internally in sufficient volumes. Read more here.

Can Benzalkonium Chloride Be Used On Cuts? 

The process of dermal wound healing can be accelerated by the application of active ingredients, such as benzalkonium chloride (BKC). BKC is a widely used disinfectant as well as a bactericidal to prevent infection in wounds. Read more here.

Benzalkonium Chloride Disinfectant

Benzalkonium chloride is widely used as a preservative in eyedrops; in higher concentrations it is used as an antiseptic and disinfectant. Read more here.

Benzalkonium Chloride Disinfectant Spray

Brief Summary: The aim of the study is to evaluate the irritation potential of benzalkonium chloride disinfectant spray when placed in contact with normal human skin. Detailed Description: Benzalkonium chloride is recognized as safe and effective for short term use as first aid antiseptic drug products. Read more here.

Benzalkonium Chloride Products

Benzalkonium chloride can be found in household cleaning products, such as laundry rinses/detergents, personal care products, wet wipes, antiseptics, eye drops and ophthalmic solutions, nasal sprays and asthma inhalers (tiotropium), dental products and Plaster of Paris. Read more here.

Benzalkonium Chloride Wipes

Benzalkonium Chloride wipes also known as, towelettes, are used as a skin disinfectant. They are ideal for cleansing a wound. Effective against bacteria, viruses, fungi and protozoa. They are often used to prep the skin around the urethra before using a catheter. Read more here.

Benzalkonium Chloride Poisoning

Benzalkonium chloride is a human skin and severe eye irritant. It is a suspected respiratory toxicant, immunotoxicant, gastrointestinal toxicant and neurotoxicant. Benzalkonium chloride formulations for consumer use are dilute solutions. Concentrated solutions are toxic to humans, causing corrosion/irritation to the skin and mucosa, and death if taken internally in sufficient volumes. 0.1% is the maximum concentration of benzalkonium chloride that does not produce primary irritation on intact skin or act as a sensitizer. Poisoning by benzalkonium chloride is recognised in the literature. A 2014 case study detailing the fatal ingestion of up to 8.1 oz (240ml) of 10% benzalkonium chloride in a 78-year-old male also includes a summary of the currently published case reports of benzalkonium chloride ingestion. While the majority of cases were caused by confusion about the contents of containers, one case cites incorrect pharmacy dilution of benzalkonium chloride as the cause of poisoning of two infants. Benzalkonium chloride poisoning of domestic pets has been recognised as a result of direct contact with surfaces cleaned with disinfectants using benzalkonium chloride as an active ingredient. As many as 20 people were killed in Japan, by a nurse injecting this.

Benzalkonium Chloride Topical Side Effects 

Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Read more here.

Benzalkonium Chloride Preservative

Benzalkonium chloride (BAK) is a preservative that has been used in ophthalmology since the 1940s, and is found in up to 70% of eye drops. BAK, a quaternary ammonium compound, acts as a detergent, lysing cell membranes, and killing microorganisms. This makes it very effective as a preservative. Read more here.

Benzalkonium Chloride Eye Drops 

Benzalkonium chloride (BAK) is the most commonly used eye drop preservative. Benzalkonium chloride has been associated with toxic effects such as “dry eye” and trabecular meshwork degeneration, but the underlying biochemical mechanism of ocular toxicity by BAK is unclear. Read more here.

Benzalkonium Chloride Mechanism Of Action 

Benzalkonium chloride (BAC) is a wide spectrum quaternary ammonium antibacterial agent that has been used in various dental composites. It is cationically charged and induces antibacterial action through attraction to the negatively charged bacterial membrane. Read more here.

Benzalkonium Chloride For Wounds 

The process of dermal wound healing can be accelerated by the application of active ingredients, such as benzalkonium chloride (BKC). BKC is a widely used disinfectant as well as a bactericidal to prevent infection in wounds. Its antimicrobial activity has been proven in many previous studies. Read more here.

Benzalkonium Chloride For Dog Wounds

Nutri-Vet Antimicrobial Wound Spray for dogs is an easy-to-use antiseptic for dog wound care. Benzalkonium Chloride works as an antiseptic and is one of the safest synthetic biocides. Soothing aloe contains enzymes, proteins, and growth factors that reduce inflammation, promote healing, and reduce pain. Read more here. Benzalkonium Chloride is used for animal wound care and skin care.

Benzalkonium Chloride For Cold Sores

The FDA found that the active ingredient, benzalkonium chloride, is not indicated as a cold sore treatment and may not make cold sore healing claims because there is no scientific evidence to support claims that it heals cold sores. Read more here.

Benzalkonium Chloride For Ringworm

AgriLabs Foot Rot and Ringworm Spray (benzalkonium chloride) for use on cattle, sheep, horses, dogs and cats as an aid in the control of Summer Itch, Girth Itch, Foot Rot, Ringworm and other fungal problems. Read more here.

Benzalkonium Chloride For Cats 

It is a fact that benzalkonium chloride is toxic to cats. The “primary adverse effects from benzalkonium chloride exposure are due to its irritancy which results in local tissue damage,” notes International Cat Care. Read more here.

Benzalkonium Chloride Uses

How Does Benzalkonium Chloride Work? 

Benzalkonium Chloride is primarily used as a preservative and antimicrobial agent, and secondarily used as a surfactant. It works by killing microorganisms and inhibiting their future growth, and for this reason frequently appears as an ingredient in antibacterial hand wipes, antiseptic creams and anti-itch ointments. Read more here.

Benzalkonium Chloride Uses In Agriculture

On account of its non-toxic, non-corrosive, non-tainting, non-staining characteristics, benzalkonium chloride is the main active use in the formulation of disinfectants and bactericidal sanitisers for healthcare, personal hygiene, the public sector and to safeguard our agriculture and food supply. Read more here.

 

Information On Benzalkonium Chloride From Wikipedia

Benzalkonium chloride, also known as BZK, BKC, BAK, BAC, alkyldimethylbenzylammonium chloride and ADBAC, is a type of cationic surfactant. It is an organic salt classified as a quaternary ammonium compound. It has three main categories of use: as a biocide, a cationic surfactant, and as a phase transfer agent. ADBACs are a mixture of alkylbenzyldimethylammonium chlorides, in which the alkyl group has various even-numbered alkyl chain lengths. Read more here.

Solubility And Physical Properties 

Depending on purity, benzalkonium chloride ranges from colourless to a pale yellow (impure). Benzalkonium chloride is readily soluble in ethanol and acetone. Dissolution in water is slow. Aqueous solutions should be neutral to slightly alkaline. Solutions foam when shaken. Concentrated solutions have a bitter taste and a faint almond-like odour. Standard concentrates are manufactured as 50% and 80% w/w solutions, and sold under trade names such as BC50, BC80, BAC50, BAC80, etc. The 50% solution is purely aqueous, while more concentrated solutions require incorporation of rheology modifiers (alcohols, polyethylene glycols, etc.) to prevent increases in viscosity or gel formation under low temperature conditions.

Cationic Surfactant 

Benzalkonium chloride also possesses surfactant properties, dissolving the lipid phase of the tear film and increasing drug penetration, making it a useful excipient, but at the risk of causing damage to the surface of the eye°.

  • Laundry detergents and treatments
  • Softeners for textiles

Phase Transfer Agent

Benzalkonium chloride is a mainstay of phase-transfer catalysis, an important technology in the synthesis of organic compounds, including drugs.

Bioactive Agents

Especially for its antimicrobial activity, benzalkonium chloride is an active ingredient in many consumer products:

  • Pharmaceutical products such as eye, ear and nasal drops or sprays, as a preservative
  • Personal care products such as hand sanitizers, wet wipes, shampoos, deodorants and cosmetics
  • Skin antiseptics, such as Bactine and Dettol.
  • Throat lozenges and mouthwashes, as a biocide
  • Spermicidal creams
  • Over-the-counter single-application treatments for herpes, cold-sores, and fever blisters, such as RELEEV and Viroxyn
  • Burn and ulcer treatment
  • Spray disinfectants for hard surface sanitization
  • Cleaners for floor and hard surfaces as a disinfectant, such as Lysol
  • Algaecides for clearing of algae, moss, lichens from paths, roof tiles, swimming pools, masonry, etc.

Benzalkonium chloride is also used in many non-consumer processes and products, including as an active ingredient in surgical disinfection. A comprehensive list of uses includes industrial applications. An advantage of benzalkonium chloride, not shared by ethanol-based antiseptics or hydrogen peroxide antiseptic, is that it does not cause a burning sensation when applied to broken skin.[citation needed] However, prolonged or repeated skin contact may cause dermatitis.

Medicine

Benzalkonium chloride is a frequently used preservative in eye drops; typical concentrations range from 0.004% to 0.01%. Stronger concentrations can be caustic[6] and cause irreversible damage to the corneal endothelium. Avoiding the use of benzalkonium chloride solutions while contact lenses are in place is discussed in the literature.

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