Dimethylformamide, N,N-Dimethylmethanamide, Dimethyl formamide, N-Formyldimethylamine, DMF
HPLC Grade

Dimethylformamide (DMF), HPLC Grade is a hygroscopic, transparent, colorless liquid with a faint amine odor. The high dielectric constant, aprotic nature of the solvent, wide range of solubility, and low volatility makes it suitable for a number of key applications. These characteristics make it a potential universal solvent.  Lab Alley recommends its premium quality DMF for research labs to obtain reliable and consistent results.

HPLC Grade Dimethylformamide (DCM) For Sale Online In The United States

High purity (99.8%) HPLC Grade dimethylformamide purchased from Lab Alley meets the HPLC Reagent Grade specifications published by the American Chemical Society. DCM is used for analytical purpose and research work. having high purity. AR Grade is the standard Mallinckrodt grade of analytical reagents; suitable for laboratory and general use. 

About Dimethylformamide (DMF)

The preparation of Dimethylformamide—strictly, N,N-dimethylformamide from dimethylamine chloride and formic acid was first described by A. Verley in 1893. It is also a common solvent for spectroscopy and a component of paint strippers.

DMF is a colorless, water-soluble liquid with a faint ammonia-like odor. The preferred IUPAC name is N,N-Dimethylformamide. This organic solvent is used in acrylic fiber spinning, chemical manufacturing, and pharmaceutical production; it is also present in textile dyes and pigments, paint stripping solvents, and coating, printing and adhesive formulations.

Dimethylformamide (DMF) is an organic compound and organic solvent sold online by Lab Alley in the USA. Dimethylformamide (DMF) is manufactured in large quantities through-out the world. The formula Dimethylformamide for is C3H7NO. Dimethylformamide is commonly abbreviated as DMF. It is used in the chemical industry in the U.S as an additive, solvent an intermediate. The laboratory grade Dimethylformamide purchased online here is virtually anhydrous and only contains 0.15% water.

The growth of the dimethylformamide market is driven by increased demand for dimethylformamide from various end-use industries such as chemical, electronics, pharmaceutical, and agrochemical. Moreover, the increased use of synthetic leather in the footwear and automotive industries is also expected to drive the growth of the the dimethylformamide market as DMF is used for manufacturing synthetic leather and wet-type polyurethane artificial leather.

Dimethylformamide Structure

N,N-Dimethylformamide (DMF) is an extraordinary organic compound with the formula (CH3)2NC(O)H. It generally abbreviated and literally always called, DMF (should not be mistaken with dimethylfuran or dimethyl fumarate). It is a colourless liquid with a high boiling point which is miscible with water and also with a majority of common organic solvents. For information on dimethylformamide NMR, click here. DMF is also used as an organic reagent in some reactions.

Dimethylformamide Polarity

As its name indicates, it is a derivative of formamide, the amide of formic acid. DMF is a polar (hydrophilic) aprotic solvent with a high boiling point. It facilitates reactions that follow polar mechanisms, such as SN2 reactions.


Dimethylformamide, HPLC Grade, 99.8% Features:

Assay [HCON(CH3)2] Min 99.8%
Appearance Clear
Color(APHA) 15
Residue after Evaporation 0.005%
Titrable Base 0.003 meq/g
Titrable Acid 0.0005 meq/g
Water 0.15%
Common Uses
  • Reagent
  • Catalyst
  • Stabilizer
Commercial/Industrial Applications
  • Herbal extraction
  • Synthetic leather production
  • Pharmaceutical industries
  • Agrochemical

Dimethylformamide (DMF) Is Used As A Plant Extraction And Botanical Solvent In The United States

Dimethylformamide (DMF) is frequently ordered from Lab Alley in order to be used for chemical reactions and other applications, which require a high solvency power. Scientists have studied and analyzed the impact of different types of solvents, such as dimethylformamide (DMF), methanol, hexane, and ethyl alcohol, for the purpose of antioxidant extraction from various plants parts, such as leaves and seeds. In order to extract different phenolic compounds from plants with a high degree of accuracy, various solvents of differing polarities must be used.

Acetone and dimethylformamide mixtures are used to extract important pigments from plants such as Chlorophylls (Chl). Dimethylformamide and acetone are used to extract pigments and carotenoids, including xanthophylls, from plant tissues. dimethylformamide is a common organic solvent used by agricultural plant scientists for pigment extraction as well as the extraction, isolation and identification of antioxidants, phytochemicals and bioactive compounds from plant extracts. methanol and ethanol are also used to extract phenolic contents from fruits.

Even though it can be difficult to do, DMF is a residual solvent that should be removed from chemical reaction mixtures that are used during botanical, plant and herbal extraction processes that produce medicinal concentrates.

Dimethylformamide (DMF) Is Used To Manufacture Acrylic Fibers

The product is known as a universal solvent. The high solubility of polyacrylonitrile in DMF, together with the good miscibility of DMF in water makes DMF the preferred solvent for the production of acrylic fibers in the acrylic fiber manufacturing industries.

How Is Dimethylformamide Used In America?

The primary use of DMF purchased from Lab Alley is as a solvent with low evaporation rate. DMF is used in the production of acrylic fibers and plastics. It is also used as a solvent in peptide coupling for pharmaceuticals, in the development and production of pesticides, and in the manufacture of adhesives, synthetic leathers, fibers, films, and surface coatings.

N,N-Dimethylformamide (DMF) is frequently used as an aprotic solvent in chemical transformations in laboratories of academia as well as in those of chemical industry. DMF is actually something much more than a solvent. It is a unique chemical since, as well as being an effective polar aprotic solvent, it can play three other important roles in organic chemistry. It can be used as a reagent, a catalyst, and a stabilizer.

It plays multiple roles in various reactions such as solvent, dehydrating agent, reducing agent as well as catalyst. It is a multipurpose building block for the synthesis of compounds containing O, -CO, -NMe2, -CONMe2, -Me, -CHO as functional groups. N,N-Dimethylformamide is a polar solvent commonly used in organic synthesis. It also acts as a multipurpose precursor for formylation, amination, aminocarbonylation, amidation and cyanation reactions.

Dimethylformamide For Peptide Synthesis

Dimethylformamide (DMF) is one of the most commonly used solvents in solid‐phase peptide synthesis (SPPS). In recent years, there has been increasing concern over the environmental, health, and safety (EHS) profile of DMF, with many solvent selection guides categorising DMF as hazardous. Read more here.

Safety and Handling

Dimethylformamide Toxicity

DMF has long been known to be toxic to the liver. Dimethylformamide is readily absorbed through the skin, inhaled, or ingested. DMF is a potent liver toxin. DMF may cause abdominal pain, constipation, nausea and vomiting, headache, weakness, dizziness, skin problems, and alcohol intolerance. Current evidence associating DMF with cancer in humans is not conclusive. Toxic amounts of dimethylformamide may be absorbed by inhalation and through the skin. To learn how to prevent adverse health effects from exposure to dimethylformamide, click here. After 2020, solvents like dimethylformamide are likely to be restricted under the EU’s Reach regulations. Consumer products such as backpacks can expose you to chemicals such as dimethylformamide, which is known to the State of California to cause cancer.

Dimethylformamide AR Shipping Information:
DOT: N,N-Dimethylformamide, 3, UN2265, PG III

To request a dimethylformamide safety data sheet (SDS) or dimethylformamide material safety data sheet (MSDS) from Lab Alley, click here.