Chlorobutanol, or trichloro-2-methyl-2-propanol, is an analgesic and sedative hypnotic in man, and an experimental general anesthetic. It has antibacterial and antifungal properties. It is also used chemical preservative for parenteral drugs. It was found, that chlorobutanol inhibited mammalian Nav 1.2 channels at concentrations less than those used to preserve parenteral solutions. Its mechanism of inhibiting Na channels differs from that of local anesthetics in that it does not show use dependent or state dependent inhibition.
Chlorobutanol is a well accepted widely used, very effective preservative in many pharmaceuticals and cosmetic products, e.g. injections, ointments, products for eyes, ears and nose, dental preparations, etc. It has antibacterial and antifungal properties and has been used for more than 130 years when it was first manufactured. Chlorobutanol is typically used at a concentration of 0.5 % where it lends long term stability to multi-ingredient formulations. Chlorobutanol, or chlorbutol, is an alcohol-based preservative with no surfactant activity. Chlorobutanol is a medicine available in a number of countries worldwide. Topical application or Chlorobutanol gels may cause
Chemical Composition Of Chlorobutanol, Hemihydrate Sold Online At LabAlley.com
|Assay (C4H7Cl3O; Anhydrous basis)||98.0-100.5%|
|Reaction (to Litmus)||Neutral|
|Organic Volatile Impurities||To Pass Test|
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