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Overview Of Zinc Chloride

Formula ZnCl₂ | Ionic Salt | CAS Number 7646-85-7 | Very Soluble In Water | Condensing & Dehydrating Agent, Wood Preservative, Deodorant, Disinfectant | Uses: For Teeth, Canker Sores, Textile Processing, Metallurgical Fluxes, Chemical Synthesis, Mouth Ulcers, Skin, Hair Growth, Bad Breath

Information On Zinc Chloride From Wikipedia

Zinc chloride is the name of chemical compounds with the formula ZnCl2 and its hydrates. Zinc chlorides, of which nine crystalline forms are known, are colorless or white, and are highly soluble in water. ZnCl2 itself is hygroscopic and even deliquescent. Samples should therefore be protected from sources of moisture, including the water vapor present in ambient air. Zinc chloride finds wide application in textile processing, metallurgical fluxes, and chemical synthesis. No mineral with this chemical composition is known aside from the very rare mineral simonkolleite, Zn5(OH)8Cl2·H2O.

Zinc Chloride Chemical Properties And Reference Information 

Zinc - Antiviral Benefits | YouTube Video


More Information From Wikipedia On Zinc Chloride

Zinc Chloride For Viruses

The idea that zinc could be used to treat the common cold originated from a 1974 paper in Nature which showed that zinc blocks the replication of rhinoviruses in cell culture. Viral plaque formation was inhibited over 99% when 0.1 millimolar zinc chloride was included in the agar overlay.

Information On Zinc Chloride From PubChem

Zinc Chloride is an ionic salt essential for the synthesis of cholesterol, protein, and fats. Zinc plays an important role in the proper functioning of the immune system. Zinc is required for the enzyme activities necessary for cell division, cell growth, and wound healing as well as the release of vitamin A from the liver. It plays a role in the acuity of the senses of smell and taste and is required to maintain prostate reproductive health and insulin function. Zinc is also involved in the metabolism of carbohydrates. Zinc chloride is administered orally or parenterally as a nutritional supplement. Zinc chloride, solution is a colorless liquid. It is mildly corrosive to metals. It causes burns to eyes, skin and mucous membranes. Read more here.

Uses Of Zinc Chloride

Zinc Chloride For Teeth

During a 14-day test period a 0.2% and a 0.4% zinc chloride solution have been examined concerning their antibacterial efficiency on the total streptococcus flora of dental plaque under conditions conforming to standard by means of the Mylar foil technique. The results of the microbiological examination show a significant decrease of colony developing units of the plaque streptococci by a 7-day mouth rinsing with zinc chloride solution. The lesser antimicrobial effect of the zinc chloride solution compared with a 0.2% chlorhexidine solution is not proved statistically in the test period. A 0.2% or 0.4% zinc chloride solution could complete the mechanical dental and oral hygiene in an effective way.

Zinc is another trace mineral, and can naturally be found in saliva. It has been proven to fight against the growth of bacteria and plaque, which can decay teeth and gum tissues, causing cavities and gum disease. 

Zinc Chloride For Hair Growth

Zinc plays an important role in hair tissue growth and repair. It also helps keep the oil glands around the follicles working properly. Hair loss is a common symptom of zinc deficiency. Bottom Line: The mineral zinc can improve hair growth in people who are deficient in it.

Is Zinc Good For Your Teeth?

Zinc is another trace mineral, and can naturally be found in saliva. It has been proven to fight against the growth of bacteria and plaque, which can decay teeth and gum tissues, causing cavities and gum disease.

World-First Trial To Test Benefit Of Intravenous Zinc In COVID-19 Fight

Previous studies have shown zinc is effective at slowing the rate of other respiratory infections, such as SARS.

Summary: University of Melbourne researchers are conducting trials to see if intravenous administration of zinc chloride will help combat some of the effects of COVID-19. Previous studies have shown zinc is effective at slowing the rate of other respiratory infections, such as SARS. A world-first trial will see researchers from Austin Health and the University of Melbourne use intravenous zinc to fight the symptoms of coronavirus (COVID-19). The trial will be led by Dr Joseph Ischia from Austin Health, along with Dr Oneel Patel from the Department of Surgery at the University of Melbourne, who has a long history of investigating the protective effects of intravenous zinc against organ damage induced by lack of oxygen. Dr Ischia said COVID-19 is especially dangerous because it replicates inside a patient’s body which can lead to respiratory conditions like bronchitis and pneumonia. “If COVID-19 enters a patient’s lungs then they often need to be placed on a ventilator to help their breathing and, in severe cases, COVID-19 can cause multiple organ failure and brain injury due to a lack of oxygen,” Dr Ischia said. Dr Patel said studies have shown that zinc is very effective at slowing the rate that similar viruses such as SARS (Severe Acute Respiratory Syndrome) and common cold (a type of coronavirus) replicate in the body.  “Our published studies have also shown that high doses of zinc can protect vital organs such as the heart, kidneys and liver against the damage caused by a lack of oxygen,” Dr Patel said. The clinical trial has been fast-tracked to test whether receiving a daily injection of zinc chloride will benefit patients with coronavirus. “There is currently no specific treatment available for patients who have COVID-19 and are at high risk of respiratory failure, which means this study has the potential to have an enormous positive impact on their clinical outcomes,” Dr Ischia said. “Importantly, we hope to show that we can save lives by limiting the impact of the symptoms. We are expecting to have preliminary results of the trial available after only seven days so we will know very quickly how effective this treatment is.” The trial is the culmination of a rapid collaboration between surgeon scientists as well as intensive care, infectious diseases and respiratory medicine doctors at Austin Health, working with the Australian pharmaceutical firm, Phebra. Phebra Chief Executive Officer Dr Mal Eutick said intravenous (IV) zinc injections, manufactured at Phebra’s multi-purpose sterile injectables plant in Sydney, would be used in the trial. “Zinc has been proven to be effective in treating severe pneumonia and other viruses although not COVID-19 to date. This trial is an extraordinary opportunity to discover if IV zinc can help us respond to the current pandemic,” Dr Eutick said “If successful this could save lives and with this trial we should know in a short time frame. In particular, it could be very important for those high risk elderly patients and also help reduce the level of general anxiety in the community.” However, both Dr Ischia and Dr Eutick warned of the need to manage the risk of zinc overdose for patients.

Zinc Chloride For Canker Sores And Mouth Ulcers

Orajel is an over the counter medication used to relieve mouth pain. Oragel Mouth Sore Gel contains 3 ingredients: benzocaine, benzalkonium, and zinc chloride. Benzocaine belongs to a group of drugs called pain reliever. It works to numb the affected area. Benzalkonium belongs to a group of drugs called antiseptic which cleanses the area. Zinc chloride belongs to a group of drugs called astringent. It works to constrict the tissue. This medication comes in a gel and is applied four times a day. Common side effects of Orajel Mouth Sore Gel include burning, stinging, and itching.

Zinc Chloride For Skin

Zinc Chloride is a white crystalline solid. Zinc Chloride induces a tightening or tingling sensation of the skin and helps to cleanse the skin or to prevent odor by destroying or inhibiting the growth of microorganisms.

Is Zinc Chloride Safe For Dogs? 

If your pet ingests a topical cream containing zinc, you may not need to worry unless it was ingested multiple times or in large amounts. However, certain types of topical medications (e.g., skin cancer or psoriasis treatments) can be very dangerous – or even deadly - to pets.

Antiviral Activity Of Zinc Salts Against Transmissible Gastroenteritis Virus In Vitro

Zinc has been shown to mediate antiviral effects against certain viruses. However, the underlying mechanisms are still largely unknown. We investigated the effects of the two zinc salts, zinc chloride (ZnCl(2)) and zinc sulfate (ZnSO(4)), on infection of swine testicle (ST) cells with transmissible gastroenteritis virus (TGEV) and compared it to the effects of a control salt, magnesium sulfate (MgSO(4)). Virus yield reduction experiments showed that ZnCl(2) and ZnSO(4) did not exhibit direct virucidal effects and did not affect adsorption of TGEV to ST cells. However, ZnCl(2) and ZnSO(4) markedly reduced viral titers as well as TGEV RNA and viral protein synthesis when applied during virus penetration and at different time points after viral cell entry. The results of the study suggest that zinc salts do not interfere with TGEV-cell binding but that they mediate antiviral effects through inhibition of viral penetration or egress or the intracellular phase of the viral life-cycle.

Zinc Chloride For Bad Breath

In its aqueous state, such as in a mouthwash, zinc chloride neutralizes the odor caused by bad breath germs for long-lasting fresh breath. It also works by controlling the growth of bad breath bacteria. It is also used in other temporary breath fresheners such as mints, sprays, lozenges and even chewing gum.

Zinc Inhibits Rhinovirus Replication

The title of this post should not come as a surprise to readers of virology blog – it was shown in 1974 that zinc could interfere with replication of rhinoviruses (see “Zinc and the common cold“). I am referring to the result of my first experiment to study the mechanism of zinc inhibition – something I promised I would document on these pages.

I am interested in understanding how zinc inhibits rhinovirus replication. Answering this question could lead to new ways to prevent common colds caused by these viruses. The first step was to reproduce the effect of zinc in my laboratory with my stocks of rhinovirus. I selected rhinovirus type 1a for my initial experiments because we’ve worked with this serotype in the past: we know the genome sequence and how the virus behaves in a mouse model. I started by doing a plaque assay with and without zinc in the medium. I prepared tenfold dilutions of virus and inoculated separate monolayers of HeLa cells with 2000, 200, and 20 plaque forming units. After allowing the virus to attach to cells for 45 minutes, I added an agar overlay to the cells with or without zinc chloride (ZnCl2). I selected 0.1 millimolar ZnCl2 because that is the concentration which had been reported to effectively inhibit plaque formation by rhinovirus type 1a. The plates were incubated for four days at 32°C and then stained. The results are shown in the photo. Plaque assays are typically done in duplicate but for simplicity only one plate of each dilution is shown.

Twenty plaques were observed on the highest dilution of virus plated in the absence of ZnCl2. Ten-fold lower dilutions produced increases in plaque number, although the plaques are too numerous to count. In the presence of ZnCl2, no plaques were observed on cells inoculated with 20 PFU. A few plaques are observed on the intermediate dilution and many more on the lowest dilution. Plaques observed in the presence of ZnCl2 are smaller than those observed in the absence of the metal.

Zinc: A Potential Antiviral Against Hepatitis E Virus Infection?

Hepatitis E virus (HEV) is a major cause of viral hepatitis worldwide. Owing to its feco oral transmission route, sporadic as well as epidemic outbreaks recurrently occur. No specific antiviral therapy is available against the disease caused by HEV. Broad spectrum antivirals such as ribavirin and interferon alfa are prescribed in severe and chronic HEV cases. However, the side effects, cost, and limitations of usage render the available treatment unsuitable for several categories of patients. We recently reported the ability of zinc to inhibit viral replication in mammalian cell culture models of HEV infection. Zinc will be a safe and economical antiviral therapy option if it inhibits HEV replication during the natural course of infection. This essay discusses the putative mechanism(s) by which zinc inhibits HEV replication and provides an overview of the possible therapeutic potential of zinc in HEV patients.

What Is The Physical State Of Zinc Chloride?

Physical properties: Zinc chloride is a white hygroscopic crystalline solid. Its density is 1.01 g mL-1. Zinc chloride melting point is 162-172 ºC and its boiling point is 220 ºC. It is soluble in water, ethanol, glycerol and acetone.

Is Zinc Chloride Safe In Mouthwash?

Zinc chloride has a long safe history of use as an effective mouthwash ingredient. Many experts believe the addition of zinc ions in mouthwash is the best way to help reduce germs that produce sulfur gases, a major component of bad breath.

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture


Increasing the intracellular Zn2+ concentration with zinc-ionophores like pyrithione (PT) can efficiently impair the replication of a variety of RNA viruses, including poliovirus and influenza virus. For some viruses this effect has been attributed to interference with viral polyprotein processing. In this study we demonstrate that the combination of Zn2+ and PT at low concentrations (2 µM Zn2+ and 2 µM PT) inhibits the replication of SARS-coronavirus (SARS-CoV) and equine arteritis virus (EAV) in cell culture. The RNA synthesis of these two distantly related nidoviruses is catalyzed by an RNA-dependent RNA polymerase (RdRp), which is the core enzyme of their multiprotein replication and transcription complex (RTC). Using an activity assay for RTCs isolated from cells infected with SARS-CoV or EAV—thus eliminating the need for PT to transport Zn2+ across the plasma membrane—we show that Zn2+ efficiently inhibits the RNA-synthesizing activity of the RTCs of both viruses. Enzymatic studies using recombinant RdRps (SARS-CoV nsp12 and EAV nsp9) purified from E. coli subsequently revealed that Zn2+ directly inhibited the in vitro activity of both nidovirus polymerases. More specifically, Zn2+ was found to block the initiation step of EAV RNA synthesis, whereas in the case of the SARS-CoV RdRp elongation was inhibited and template binding reduced. By chelating Zn2+ with MgEDTA, the inhibitory effect of the divalent cation could be reversed, which provides a novel experimental tool for in vitro studies of the molecular details of nidovirus replication and transcription.

Author Summary 

Positive-stranded RNA (+RNA) viruses include many important pathogens. They have evolved a variety of replication strategies, but are unified in the fact that an RNA-dependent RNA polymerase (RdRp) functions as the core enzyme of their RNA-synthesizing machinery. The RdRp is commonly embedded in a membrane-associated replication complex that is assembled from viral RNA, and viral and host proteins. Given their crucial function in the viral replicative cycle, RdRps are key targets for antiviral research. Increased intracellular Zn2+ concentrations are known to efficiently impair replication of a number of RNA viruses, e.g. by interfering with correct proteolytic processing of viral polyproteins. Here, we not only show that corona- and arterivirus replication can be inhibited by increased Zn2+ levels, but also use both isolated replication complexes and purified recombinant RdRps to demonstrate that this effect may be based on direct inhibition of nidovirus RdRps. The combination of protocols described here will be valuable for future studies into the function of nidoviral enzyme complexes. Read more here.

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