Mannitol Reagent ACS Features:
|Specific Rotation, [a]2D5||+24.1|
|Loss on Drying 0.05%||0.05%|
|Residue after Ignition||0.01%|
|Titrable Acids||0.0008 meq/g|
Mannitol Powder Product Summary
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- Formula C6H14O6
- CAS # 64-65-8
- Used: For Parkinson's Disease, Sugar Alcohol And Sweetener, For Glaucoma, Medical Uses, Food Uses, For Analytical Chemistry
About Mannitol Powder
Mannitol is a type of carbohydrate called a sugar alcohol, or polyol. Mannitol contains about 60 percent fewer calories than sugar and is half as sweet. Mannitol occurs naturally in fresh mushrooms, brown algae, tree bark and most fruits and vegetables.
D-mannitol is the D-enantiomer of mannitol. It has a role as an osmotic diuretic, a sweetening agent, an antiglaucoma drug, a metabolite, an allergen, a hapten, a food bulking agent, a food anticaking agent, a food humectant, a food stabiliser, a food thickening agent, an Escherichia coli metabolite and a member of compatible osmolytes.
Mannitol is an osmotic agent and a free radical scavenger. It acts by drawing fluid out of tissue into the vascular compartment. It also reduces blood viscosity and hence increases cerebral blood flow, which results in an autoregulatory vasoconstriction that may reduce ICP.
Randomized clinical trial comparing sodium picosulfate with mannitol on the preparation FOR colonoscopy in hospitalized patients. The cleansing of the colon for a colonoscopy exam must be complete so as to allow the visualization and inspection of the intestinal lumen. The ideal cleansing agent should be easily administered, have a low cost, and minimum collateral effects. Sodium picosulfate together with the magnesium citrate is a cathartic stimulant and mannitol is an osmotic laxative, both usually used for this purpose.
Effective and safe mannitol administration in patients undergoing supratentorial tumor surgery: A prospective, randomized and double blind study. Although osmotic diuresis with mannitol is commonly used to provide brain relaxation, there is no consensus regarding its optimal dose and combination with loop diuretics. The aim of the present study is to evaluate the effects of mannitol and combination of furosemide with different doses of mannitol on brain relaxation and on blood electrolytes, lactate level, urine output, fluid balance and blood osmolarity in patients undergoing supratentorial tumor surgery.
Safety, Tolerability and Effects of Mannitol in Parkinson's Disease (PD-mannitol)
Parkinson's disease is a progressive neurodegenerative disease that causes disabling motor and cognitive impairments. Currently, no disease-modifying therapy exists for this disease. Mannitol, a naturally-occurring substance, which is commonly used as sweetener, was offered as such agent. In this phase II, safety, tolerability-based dose finding, and efficacy study, mannitol or placebo (dextrose) in escalating doses will be given to patients with Parkinson's disease for 36 weeks.
Mannitol’s safety has been reviewed and confirmed by health authorities around the world, including the World Health Organization, the European Union, and the countries Australia, Canada and Japan. The U.S. Food and Drug Administration (FDA) also recognizes mannitol as safe.
Symptoms of exposure to Mannitol include nausea, vomiting, headache, chills, chest pain and pulmonary edema. It may cause irritation of the skin, eyes and respiratory tract. Other symptoms may include lethargy, confusion, heart failure and death. Exposure has caused an electrolyte and fluid imbalance, hypersensitivity reactions, diarrhea, thirst, fever, tachycardia, hyponatremia, urinary retention, dehydration, blurred vision, convulsions, urticaria, hypotension and hypertension. It has also caused hyperglycemia and glycosuria. Coughing may result from inhalation. Ingestion may cause gastric irritation. Skin contact may cause discoloration of sensitive skin. Eye contact may cause redness and pain. Intravenous use has led to blood pressure elevation and bladder tubule changes. ACUTE/CHRONIC HAZARDS: This compound may cause irritation of the skin, eyes and respiratory tract. When heated to decomposition it emits acrid smoke and toxic fumes of carbon monoxide and carbon dioxide.
Please contact us to request a Safety Data Sheet (SDS) and Certificate of Analysis (COA) for Mannitol Reagent ACS.