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About Polysorbate 80 (PS80)
Polysorbate 80 is a nonionic surfactant and emulsifier often used in foods and cosmetics. This synthetic compound is a viscous, water-soluble yellow liquid. Polysorbate 80 is a hydrophilic nonionic surfactant. It is utilized as a surfactant in soaps and cosmetics and also as a lubricant in eye drops. In food or pharmaceutical products, it can act as an emulsifier. Polysorbate 80 is used as an emulsifier or defoamer in foods, vitamins, medicines, and vaccines. Buy bulk natural ingredients and antiviral raw materials for safe recipes for DIY homemade hand sanitizers here.
Polysorbate 80 Chemical Properties And Reference Resources
- Polysorbate 80 CAS Registry Number: 9005-65-6
- Polysorbate 80 Molar mass: 1,310 g/mol
- Polysorbate 80 Formula: C64H124O26
- Polysorbate 80 Density: 1.06–1.09 g/mL, oily liquid
- Polysorbate 80 Solubility In Water: Very soluble
- Polysorbate 80 Solubility In Other solvents: soluble in ethanol, cottonseed oil, corn oil, ethyl acetate, methanol, toluene
- Polysorbate 80 Boiling Point: > 100°C
- Other Names For Polysorbate 80: Montanox 80, Alkest TW 80, Tween 80, PS 80, Scattics, Canarcel, E number: E433, Polyoxyethylene sorbitan monooleate, Poegasorb 80
- Polysorbate 80 PubChem CID: 5284448
- Information On Polysorbate 80 From EWG
Polyoxyethylene sorbitan monooleate (CAS number: 9005-65-6) and polyoxyethylene sorbitan trioleate (CAS number: 9005-70-3) are oleate esters of sorbitol. The chemical name polyoxyethylene sorbitan monooleate covers the substances known by the commercial names Polysorbate 80, and Polysorbate 81. Read more here.
In food or pharmaceutical products, it can act as an emulsifier. Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration or vaccinations 15. A solubilizing agent acts as a surfactant and increases the solubility of one agent in another. Read more here.
Polysorbate 80 may or may not be vegan. It is a Polysorbate of Oleic Acid, used in foods as a stabilizer and emulsifier. Oleic Acid can have plant or animal sources. Please check with the manufacturer. Read more here.
Polysorbate 80 is used as an emulsifier in foods. For example, in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting. Adding this substance prevents milk proteins from completely coating the fat droplets. Read more here.
Polysorbate 80 has also been causally linked with an increased risk of blood clots, stroke, heart attack, heart failure, and of tumor growth or recurrence in patients with certain types of cancer. Read more here.
Polysorbate 80 is a common food additive used in several vaccines as an emulsifier (to hold other ingredients together). Compared to its use in foods, there is very little polysorbate 80 in vaccines. Read more here.
In drug formulations, polysorbate 80 has been implicated in a number of systemic reactions (e.g., hypersensitivity, nonallergic anaphylaxis, rash) and injection- and infusion-site adverse events (ISAEs; e.g., pain, erythema, thrombophlebitis). Read more here.
Some stories on the internet have suggested that polysorbate 80 in this vaccine causes infertility. First, it is important to know that the HPV vaccine does not cause infertility. Second, polysorbate 80 has been used for many years as an emulsifier to make ice cream smooth and to slow melting. Read more here.
A mixture of Tri-n-butyl phosphate (TNBP) and Polysorbate 80 (Tween 80) is often used for virus inactivation during the manufacture of medicinal products derived from human plasma. In summary, vegetable-derived Tween 80 is of the same effectiveness as bovine-derived Tween 80, when used for virus inactivation by the solvent/detergent treatment. Read more here.
Insights into Virus Inactivation by Polysorbate 80 (PS80) in the Absence of Solvent
Polysorbate 80 (PS80) in absence of any solvents was able to effectively inactive enveloped viruses such as XMuLV and PRV. PS80 did not show any virucidal activities in phosphate buffered saline (PBS) while achieving robust virus inactivation in cell‐free CHO bioreactor harvests. Subsequent characterization work has indicated that virus inactivation by PS80 is effective and robust within temperature and concentration ranges comparable to those of Triton X‐100. PS80 is potentially a viable replacement for Triton X‐100 and can be used in manufacturing processes for wide spectrum of biopharmaceuticals to achieve desirable virus clearance. Read more here.
Learn About The Antimicrobial Activity of Polyoxyethylene Sorbitan Monooleate (Tween 80/PS80) Against Aspergillus Niger And Herpes Simplex Virus Type 2
Microemulsions (MEs), which consist of oil, water, surfactants, and cosurfactants, have recently generated considerable interest as antimicrobial agents. Among the ME formulas, MEb was the only one that affected HSV-2. According to the CPE assay shown in Figure 6, ,55 µL/ (1 mL of DMEM) of MEb was sufficient to kill all of the HSV-2 virus. In other words, a 200-fold dilution of MEb was able to destroy the HSV-2 virus. Read more here.
Polysorbate 80 is a nonionic surfactant and emulsifier often used in foods and cosmetics. This synthetic compound is a viscous, water-soluble yellow liquid.
Polysorbate 80 is derived from polyethoxylated sorbitan and oleic acid. The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide. In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case the oleic acid (see polysorbate for more detail). The full chemical names for polysorbate 80 are: Polyoxyethylene (20) sorbitan monooleate and
(x)-sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl). The critical micelle concentration of polysorbate 80 in pure water is reported as 0.012 mM.
Polysorbate 80 is used as an emulsifier in foods. For example, in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting. Adding this substance prevents milk proteins from completely coating the fat droplets. This allows them to join together in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.
Health And Beauty Use
Polysorbate 80 is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer such as in a mouthwash. The cosmetic grade of polysorbate 80 may have more impurities than the food grade.
Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the popular antiarrhythmic amiodarone. It is also used as an excipient in some European and Canadian influenza vaccines. Influenza vaccines contain 2.5 μg of polysorbate 80 per dose. Polysorbate 80 is found in many vaccines used in the United States. It is also used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth. It is also used as an emulsifier in the estrogen-regulating drug Estrasorb. Also used in granulation for stabilization of drug and excipients while doing IPA binding.
Some mycobacteria contain a type of lipase (enzyme that breaks up lipid molecules); when these species are added to a mixture of polysorbate 80 and phenol red, they cause the solution to change color, so this is used as a test to identify the phenotype of a strain or isolate. On RODAC agar plates used in microbiological control, polysorbate 80 counteracts any disinfectants often found on sampled surfaces, thereby allowing the microbes found on these surfaces to grow.
Super Refined Polysorbates solubilise and stabilise the most sensitive active ingredients across dosage forms including injectable and oral. Super Refining removes impurities (including primary and secondary oxidation products) from an excipient without altering its chemical composition, helping to reduce API interaction and degradation. The benefits of Super Refined Polysorbates over standard pharmaceutical polysorbates include: Better API stability and finished formulation integrity Reduced potential for cellular irritation Improved taste profile when used in oral liquid dosage forms.
Super Refined Polysorbate 80 POA is a high purity polysorbate 80 that has been created to meet the tight specification of the Chinese Pharmacopeia for polysorbate 80 injection. This high purity, multi-compendial grade has been Super Refined allowing for further purification above the ChP monograph. This provides the potential for improved product and API stability and, ultimately, extended drug shelf life.
Super Refined Polysorbate 80 POA Pharmacopoeia Compliance
- FDA-IID Listed
Polysorbate 20 (Tween 20) is a surfactant and emulsifier used in cleaners and personal care products. The Food and Drug Administration (FDA) approves use of polysorbate 20 as a synthetic flavoring substances at specified concentrations and formulations. The Cosmetics Ingredient Review (CIR) Expert Panel evaluated the scientific data and concluded that polysorbate 20 is safe for use in cosmetic formulations. Polysorbate 20 is derived from sorbitol, a natural ingredient. However, polysorbate 20 is not a natural ingredient. In fact, it is a carcinogen due to the fact that it is treated with 20 parts of ethylene oxide. People who make their own beauty products often use polysorbate 20 as an emulsifying agent.
Evaluation Of Inactivation Methods For Severe Acute Respiratory Syndrome Coronavirus In Noncellular Blood Products
Severe acute respiratory syndrome coronavirus (SARS-CoV) has been detected in the blood of infected individuals, which may have the potential to contaminate donated blood and plasma-derived products in the event of a future outbreak. Effective methods for inactivating the SARS-CoV in protein solutions are described in this report.
Study Design And Methods:
Heat, ultraviolet (UV) irradiation, octanoic acid, and solvent/detergent (S/D) methods were tested individually for their ability to inactivate SARS-CoV in protein solutions appropriately mimicking blood-derived products. Treated samples were tested for inactivation in a tissue culture growth assay.
Viral inactivation by heat treatment at 60 degrees C required 15 to 30 minutes to inactivate the SARS-CoV. UVC efficiently inactivated SARS-CoV in 40 minutes, whereas UVA required the addition of psoralen to enhance inactivation of the virus. The presence of bovine serum albumin limited the ability of UVC and UVA to inactivate SARS-CoV and octanoic acid treatment does not reduce the infectivity of SARS-CoV-spiked protein solutions. S/D treatment required 2, 4, and up to 24 hours for Triton X-100, Tween 80, and sodium cholate inactivation, respectively.
Heat, UVC irradiation, and S/D treatments effectively inactivate SARS-CoV, whereas octanoic acid treatment is insufficient for inactivation of the virus. Read more here.