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ThyroSafe is the only FDA approved 65 mg. Potassium Iodide (KI) tablet for sale in the US. It is used to protect your thyroid gland against radioactive iodine released during a nuclear emergency. It does this by flooding the thyroid with stable, safe iodine, which blocks the absorption of dangerous radioactive iodine.
KI (potassium iodide) is available without a prescription. The Food and Drug Administration (FDA) External Web Site Icon has approved some brands of KI. People should only take KI (potassium iodide) on the advice of public health or emergency management officials.
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KI (potassium iodide) is available without a prescription. The Food and Drug Administration (FDA) External Web Site Icon has approved some brands of KI. People should only take KI (potassium iodide) on the advice of public health or emergency management officials. There are health risks associated with taking KI.
Potassium iodide is available in both prescription and over-the-counter (OTC) forms. The drug is an anti-thyroid medicine. It works by shrinking the thyroid gland and blocking radioactive iodine from entering the gland.
How Much Does Potassium Iodide Cost? [Online And In A Pharmacy]
25 grams of high purity potassium chloride crystals can be purchased online at LabAlley.com. A 10% discount code (LAB10OFF) can be used when ordering online or by phone (512-668-9918) in the U.S.
Potassium Iodide, KI, is a common nutritional supplement for both humans and animals. Most often for humans, it is used to iodize table salt. It is also a common radiation protective agent, actively protecting the thyroid gland. Shop for potassium iodide online here. Potassium iodide is a metal halide composed of potassium and iodide.
Potassium iodide is an odorless white solid. Sinks and mixes with water. Potassium iodide is a metal iodide salt with a K(+) counterion. It is a scavenger of hydroxyl radicals. It has a role as a radical scavenger and an expectorant. It contains an iodide.
Potassium iodide is a medicine that helps relieve congestion in people with breathing problems such as asthma, emphysema, or bronchitis. The drug can also be used during a nuclear radiation emergency to protect the thyroid gland from radioactive iodine. Potassium iodide is also sometimes used to treat an overactive thyroid and a skin condition known as sporotrichosis. Read more here.
30% hydrogen peroxide is added to a glass cylinder containing a concentrated aqueous mixture of potassium iodide and dishwashing soap. The iodide ion catalyzes the decomposition of hydrogen peroxide, generating oxygen gas which causes the soap to foam up and shoot up out of the cylinder. Read more here.
While acute toxicity is unlikely, chronically elevated levels of iodine can be dangerous. They can cause goiter and inhibit thyroid functioning. It would likely take several weeks of ingesting the recommended dose of potassium iodide for those disorders to occur, though. The KI tablets are also dangerous for people with allergies or certain thyroid or skin conditions. Read more here.
This fact sheet is about the NYS policy for people, especially those who live within ten miles of a nuclear power plant, who may be exposed to radiation from a nuclear plant emergency. In December 2001, the federal Food and Drug Administration (FDA) said if there was a radiation emergency, people should take a drug that would help protect them from thyroid cancer. This drug is called potassium iodide (KI). The New York State Health Department agrees. The questions and answers below will give you more information. Read more here.
Common side effects of Potassium Iodide include: Allergic reactions, Hypothyroidism, Irregular heart rate, Benign tumor of the thyroid gland, Diarrhea, Fever, Gastrointestinal irritation or bleeding, Goiter, Headache, Hyperthyroidism. Read more here.
Liquid Potassium Iodide is used to treat overactive thyroid and to protect the thyroid gland from the effects of radiation from inhaled or swallowed radioactive iodine. It may be used before and after administration of medicine containing radioactive iodine or after accidental exposure to radioactive iodine for example, from nuclear power plant accidents that involved release of radioactivity to the environment. Read more here.
ThyroSafe is the only FDA approved 65 mg. Potassium Iodide (KI) tablet for sale in the US. It is used to protect your thyroid gland against radioactive iodine released during a nuclear emergency. It does this by flooding the thyroid with stable, safe iodine, which blocks the absorption of dangerous radioactive iodine. ThyroSafe is produced by Recipharm AB who has more than 20 years experience in manufacturing Potassium Iodide tablets. Read more here.
There is no ‘best’ brand for children. Iosat™ Potassium Iodide tablets (130 mg per tablet) are the equivalent of a full-strength daily dosage for an adult, however they may also be very easily administered to children with a correct dosage, simply by splitting the pre-scored pills. ThyroSafe™ Potassium Iodide tablets are half-strength (65mg) which means one tablet a day for children (2 tablets for an adult). Read more here.
30% hydrogen peroxide is added to a glass cylinder containing a concentrated aqueous mixture of potassium iodide and dishwashing soap. The iodide ion catalyzes the decomposition of hydrogen peroxide, generating oxygen gas which causes the soap to foam up and shoot up out of the cylinder.
Pour ~50 mL of 30% hydrogen peroxide solution into the graduated cylinder. Squirt in a little dishwashing detergent and swirl it around. You can place 5-10 drops of food coloring along the wall of the cylinder to make the foam resemble striped toothpaste. Add ~10 mL of potassium iodide solution.
Potassium iodide comes as a liquid or tablet to take by mouth. It’s usually taken three to four times a day to treat cough, breathing difficulties, or hyperthyroidism. It’s usually taken once a day to protect against radiation exposure. Your dose and length of use will depend on your medical condition and response to treatment. Read more here.
Potassium iodide increased the toxic effect in selenium poisoning. Concurrent use of captopril, enalapril, or lisinopril with potassium iodide may result in hyperkalemia; serum potassium concentrations should be monitored , however usual doses of potassium iodide used for radiation protection (i.e. up to 130 mg) contain negligible amounts of potassium and should not constitute a problem with ACE inhibitors. Read more here.
The concentration of the potassium iodide solution should be adjusted so that it gives a light brown solution on addition of chlorine water. If the reagents are too concentrated, a black precipitate of iodine often results instead of a brown solution. Read more here.
Potassium iodide is a chemical compound, medication, and dietary supplement. As a medication it is used to treat hyperthyroidism, in radiation emergencies, and to protect the thyroid gland when certain types of radiopharmaceuticals are used. In the developing world it is also used to treat skin sporotrichosis and phycomycosis. As a supplement it is used in those who have low intake of iodine in the diet. It is given by mouth.
Common side effects include vomiting, diarrhea, abdominal pain, rash, and swelling of the salivary glands. Other side effects include allergic reactions, headache, goitre, and depression. While use during pregnancy may harm the baby, its use is still recommended in radiation emergencies. Potassium iodide has the chemical formula KI. Commercially it is made by mixing potassium hydroxide with iodine.
Potassium iodide has been used medically since at least 1820. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. Potassium iodide is available as a generic medication and over the counter. In the United States a course of treatment is less than US$25. Potassium iodide is also used for the iodization of salt.
The uses of KI include as a nutritional supplement in animal feeds and also the human diet. For the latter, it is the most common additive used to "iodize" table salt (a public health measure to prevent iodine deficiency in populations that get little seafood). The oxidation of iodide causes slow loss of iodine content from iodised salts that are exposed to excess air. The alkali metal iodide salt, over time and exposure to excess oxygen and carbon dioxide, slowly oxidizes to metal carbonate and elemental iodine, which then evaporates. Potassium iodate (KIO3) is used to add iodine to some salts so that the iodine is not lost by oxidation. Dextrose or sodium thiosulfate are often added to iodized table salt to stabilize potassium iodide thus reducing loss of the volatile chemical.
Pheochromocytoma seen as dark sphere in center of the body. Image is by MIBG scintigraphy with radiation from radioiodine in the MIBG. However, note unwanted uptake of radioiodine from the pharmaceutical by the thyroid gland in the neck, in both images (front and back) of the same patient. Radioactivity is also seen in the bladder. Thyroid iodine uptake blockade with potassium iodide is used in nuclear medicine scintigraphy and therapy with some radioiodinated compounds that are not targeted to the thyroid, such as iobenguane (MIBG), which is used to image or treat neural tissue tumors, or iodinated fibrinogen, which is used in fibrinogen scans to investigate clotting. These compounds contain iodine, but not in the iodide form. However, since they may be ultimately metabolized or break down to radioactive iodide, it is common to administer non-radioactive potassium iodide to ensure that iodide from these radiopharmaceuticals is not sequestered by the normal affinity of the thyroid for iodide.
Formulations Three companies (Anbex, Inc., Fleming Co, and Recipharm of Sweden) have met the strict FDA requirements for manufacturing and testing of KI, and they offer products (IOSAT, ThyroShield, and ThyroSafe, respectively) which are available for purchase. In 2012, Fleming Co. sold all its product rights and manufacturing facility to other companies and no longer exists. ThyroShield is currently not in production. The Swedish manufacturing facility for Thyrosafe, a half-strength potassium iodide tablet for thyroid protection from radiation, was mentioned on the secret US 2008 Critical Foreign Dependencies Initiative leaked by Wikileaks in 2010.
Tablets of potassium iodide are supplied for emergency purposes related to blockade of radioiodine uptake, a common form of radiation poisoning due to environmental contamination by the short-lived fission product 131I. Potassium iodide may also be administered pharmaceutically for thyroid storm.
For reasons noted above, therapeutic drops of SSKI, or 130 mg tablets of KI as used for nuclear fission accidents, are not used as nutritional supplements, since an SSKI drop or nuclear-emergency tablet provides 300 to 700 times more iodine than the daily adult nutritional requirement. Dedicated nutritional iodide tablets containing 0.15 mg (150 micrograms (μg)) of iodide, from KI or from various other sources (such as kelp extract) are marketed as supplements, but they are not to be confused with the much higher pharmaceutical dose preparations.
Potassium iodide can be conveniently prepared as a saturated solution, abbreviated SSKI. This method of delivering potassium iodide does not require a method to weigh out the potassium iodide so it can be used in an emergency situation. KI crystals are simply added to water until no more KI will dissolve and instead sits at the bottom of the container. With pure water, the concentration of KI in the solution depends only on the temperature. Potassium iodide is highly soluble in water so SSKI is a concentrated source of KI. At 20 degrees Celsius the solubility of KI is 140-148 grams per 100 grams of water. Because the volumes of KI and water are approximately additive, the resulting SSKI solution will contain about 1.00 gram (1000 mg) KI per milliliter (mL) of solution. This is 100% weight/volume (note units of mass concentration) of KI (one gram KI per mL solution), which is possible because SSKI is significantly more dense than pure water—about 1.67 g/mL. Because KI is about 76.4% iodide by weight, SSKI contains about 764 mg iodide per mL. This concentration of iodide allows the calculation of the iodide dose per drop, if one knows the number of drops per milliliter. For SSKI, a solution more viscous than water, there are assumed to be 15 drops per mL; the iodide dose is therefore approximately 51 mg per drop. It is conventionally rounded to 50 mg per drop.
The term SSKI is also used, especially by pharmacists, to refer to a U.S.P. pre-prepared solution formula, made by adding KI to water to prepare a solution containing 1000 mg KI per mL solution (100% wt/volume KI solution), to closely approximate the concentration of SSKI made by saturation. This is essentially interchangeable with SSKI made by saturation, and also contains about 50 mg iodide per drop.
Saturated solutions of potassium iodide can be an emergency treatment for hyperthyroidism (so-called thyroid storm), as high amounts of iodide temporarily suppress secretion of thyroxine from the thyroid gland. The dose typically begins with a loading dose, then 1⁄3 mL SSKI (5 drops or 250 mg iodine as iodide), three times per day.
Iodide solutions made from a few drops of SSKI added to drinks have also been used as expectorants to increase the water content of respiratory secretions and encourage effective coughing.
SSKI has been proposed as a topical treatment for sporotrichosis, but no trials have been conducted to determine the efficacy or side effects of such treatment.
Potassium iodide has been used for symptomatic treatment of erythema nodosum patients for persistent lesions whose cause remains unknown. It has been used in cases of erythema nodosum associated with Crohn's disease.
Due to its high potassium content, SSKI is extremely bitter, and if possible it is administered in a sugar cube or small ball of bread. It may also be mixed into much larger volumes of juices.
Neither SSKI or KI tablets are used as nutritional supplements, since the nutritional requirement for iodine is only 150 micrograms (0.15 mg) of iodide per day. Thus, a drop of SSKI provides 50/0.15 = 333 times the daily iodine requirement, and a standard KI tablet provides twice this much.
Recent reports postulate that the dual oxidase (DUOX) proteins function as part of a multicomponent oxidative pathway used by the respiratory mucosa to kill bacteria. The other components include epithelial ion transporters, which mediate the secretion of the oxidizable anion thiocyanate (SCN−) into airway surface liquid, and lactoperoxidase (LPO), which catalyzes the H2O2-dependent oxidation of the pseudohalide SCN− to yield the antimicrobial molecule hypothiocyanite (OSCN−). We hypothesized that this oxidative host defense system is also active against respiratory viruses. We evaluated the activity of oxidized LPO substrates against encapsidated and enveloped viruses. When tested for antiviral properties, the LPO-dependent production of OSCN− did not inactivate adenovirus or respiratory syncytial virus (RSV). However, substituting SCN− with the alternative LPO substrate iodide (I−) resulted in a marked reduction of both adenovirus transduction and RSV titer. Importantly, well-differentiated primary airway epithelia generated sufficient H2O2 to inactivate adenovirus or RSV when LPO and I− were supplied. The administration of a single dose of 130 mg of oral potassium iodide to human subjects increased serum I− concentrations, and resulted in the accumulation of I− in upper airway secretions. These results suggest that the LPO/I−/H2O2 system can contribute to airway antiviral defenses. Furthermore, the delivery of I− to the airway mucosa may augment innate antiviral immunity.
Recent studies have revealed that the human and nonrodent mammalian airway mucosa contains an oxidative host defense system. This three-component system consists of the hydrogen peroxide (H2O2)-producing enzymes dual oxidase (Duox)1 and Duox2, thiocyanate (SCN(-)), and secreted lactoperoxidase (LPO). The LPO-catalyzed reaction between H2O2 and SCN(-) yields the bactericidal hypothiocyanite (OSCN(-)) in airway surface liquid (ASL). Although SCN(-) is the physiological substrate of LPO, the Duox/LPO/halide system can generate hypoiodous acid when the iodide (I(-)) concentration is elevated in ASL. Because hypoiodous acid, but not OSCN(-), inactivates respiratory syncytial virus (RSV) in cell culture, we used a lamb model of RSV to test whether potassium iodide (KI) could enhance this system in vivo. Newborn lambs received KI by intragastric gavage or were left untreated before intratracheal inoculation of RSV. KI treatment led to a 10-fold increase in ASL I(-) concentration, and this I(-) concentration was approximately 30-fold higher than that measured in the serum. Also, expiratory effort, gross lung lesions, and pulmonary expression of an RSV antigen and IL-8 were reduced in the KI-treated lambs as compared with nontreated control lambs. Inhibition of LPO activity significantly increased lesions, RSV mRNA, and antigen. Similar experiments in 3-week-old lambs demonstrated that KI administration was associated with reduced gross lesions, decreased RSV titers in bronchoalveolar lavage fluid, and reduced RSV antigen expression. Overall, these data indicate that high-dose KI supplementation can be used in vivo to lessen the severity of RSV infections, potentially through the augmentation of mucosal oxidative defenses.
The invention relates to the field of medicine, particularly to drug of a wide range of virucide effect specifically inhibiting and /or virucide effect on DNA- and RNA containing viruses. It may be used for treating for diseases of viral nature of mammals, including humans. The claimed drug contains, as an active agent, iodine, potassium or sodium iodide, lithium chloride, a synthetic water-soluble gel-forming polymer, as well as natural polymers, mono- and oligosaccharides. The virucide drug also exhibits an immunomodulating and immunostimulating effect.