Sodium Benzoate, also known as Sodiumato Benzoatato, Antimol, Ucephan, Benzoate of Soda, and Sobenate, has the chemical formula C₇H₅O₂Na or C₇H₅NaO₂ or C₆H₅COONa. It appears as colorless or white hygroscopic crystals or crystalline powder with no odor and astringent taste. It is freely soluble in Water and sparingly soluble in Alcohol at ambient conditions. On a lab scale, it is produced synthetically by the neutralization of Benzoic Acid with Sodium Bicarbonate, Sodium Carbonate or Sodium Hydroxide. Lab grade chemicals possess reasonable purity but do not comply with any official standard for quality or purity like the ACS Grade, the USP Grade, or the FCC Grade. The Lab Grade is also known as Laboratory Reagent (LR) and Chemically Pure (CP). Lab Alley’s Sodium Benzoate, Lab Grade is available for sale online at laballey.com. It is highly recommended for educational institutes and research labs.

Sodium Benzoate [YouTube.com Video From Audiopedia]

What Is Sodium Benzoate Used For?

• Sodium Benzoate For Hyperammonemia
• Sodium Benzoate For Hepatic Encephalopathy (HE)
• Sodium Benzoate For Teeth
• Sodium Benzoate For Skin Care Products
• Sodium Benzoate For Dog Food
• Sodium Benzoate For Acne
• Sodium Benzoate For Food Preservation
• Sodium Benzoate For Pharmaceutical Applications
• Sodium Benzoate For Cosmetics
• Sodium Benzoate For Medicine
• Sodium Benzoate For Inhibition Of Corrosion
• Sodium Benzoate For Cleaning
• Sodium Benzoate Used As A Flavoring Agent In The Food Industry
• Sodium Benzoate Is Used As A Tablet And Capsule Lubricant In The Pharmaceutical Manufacturing Industry

Sodium Benzoate For Hepatic Encephalopathy [What is the role of sodium benzoate in the treatment of hepatic encephalopathy (HE)?]

Sodium benzoate interacts with glycine to form hippurate. The subsequent renal excretion of hippurate results in the loss of ammonia ions. Dosing of sodium benzoate at 5 g orally twice a day can effectively control hepatic encephalopathy. Read more here.

Sodium Benzoate For Teeth [What's in your toothpaste? An ingredient checkup.]

Preservatives. The last thing you want to be spreading all over your teeth is moldy toothpaste. Sodium benzoate, methyl paraben, and ethyl paraben are the three most common preservative ingredients used to keep your toothpaste from become home to all sorts of nasty bacteria. Read more here.

Sodium Benzoate For Skin [Sodium Benzoate - The Dermatology Review] 

Sodium benzoate is a preservative used in cosmetic and skin care products that also functions as a corrosion inhibitor. Read more here.

Sodium Benzoate For Food Preservation [Sodium benzoate - Wikipedia]

Preservative. Sodium benzoate is a preservative, with the E number E211. It is most widely used in acidic foods such as salad dressings (i.e. acetic acid in vinegar), carbonated drinks (carbonic acid), jams and fruit juices (citric acid), pickles (acetic acid), condiments, and frogurt toppings. Read more here.

Is Sodium Benzoate Harmful? [YouTube.com Video FRom NutritionFacts.org]

Sodium Benzoate For Pharmaceutical Applications [Global Sodium Benzoate Market 2017-2021: Market Insights]

Sodium benzoate is widely used in pharmaceutical applications, mainly as a preservative. It acts as an antibacterial and preservative in various pharmaceutical products such as ointments, syrups, tinctures, and oral liquid preparations. It helps in healing superficial fungal skin infections. Read more here.

Sodium Benzoate Used In Cosmetics [Is Sodium Benzoate Safe in Cosmetics?]

Sodium benzoate is used in a wide variety of cosmetics and personal care products where it acts as a corrosion inhibitor, fragrance ingredient, and preservative. As a preservative, sodium benzoate is primarily an anti-fungal agent but also has some effectiveness against bacteria. Read more here.

Sodium Benzoate For Medicine [Sodium Benzoate: Uses, Dangers, and Safety - Healthline] 

Summary Sodium benzoate medicine can be used to treat high blood ammonia levels. It is also being studied for potential use in other conditions, including schizophrenia and multiple sclerosis. Read more here.

Sodium Benzoate For Cleaning [Guide to Sodium Benzoate]

Due to sodium benzoate's preservative and antifungal properties, it is often used in conventional and even some green cleaning furniture polishes, toilet bowl cleaners, dishwashing detergent gels, carpet cleaning products, upholstery cleaners, and dishwasher cleaners. Read more here.

Information On Sodium Benzoate From Wikipedia

• Sodium Benzoate CAS Registry Number: 532-32-1
• Sodium Benzoate Formula: C7H5NaO2
• Sodium Benzoate Molar mass: 144.11 g/mol
• Sodium Benzoate Solubility In 1,4-Dioxane: 0.818 mg/kg (25 °C)
• Sodium Benzoate Solubility In Methanol: 8.22 g/100 g (15 °C); 7.55 g/100 g (66.2 °C)
• Sodium Benzoate ATC code: A16AX11 (WHO)
• Sodium Benzoate Autoignition temperature: 500 °C (932 °F; 773 K)
• Other Names For Sodium Benzoate: E211, benzoate of soda
• Sodium Benzoate PubChem CID: 517055
• Sodium Benzoate ChemSpider ID: 10305

Sodium benzoate is a substance which has the chemical formula C6H5COONa. It is a widely used food preservative, with an E number of E211. It is the sodium salt of benzoic acid and exists in this form when dissolved in water. It can be produced by reacting sodium hydroxide with benzoic acid.

Production
Sodium benzoate is produced by the neutralization of benzoic acid, which is itself produced commercially by partial oxidation of toluene with oxygen.

Natural occurrence
Sodium benzoate does not occur naturally, but benzoic acid and its esters are found in many foods. Fruits and vegetables can be rich sources, particularly berries such as cranberry and bilberry. Other sources include seafood, such as prawns, and dairy products like milk, cheese, and yogurt.

Uses
Preservative
Sodium benzoate is a preservative, with the E number E211. It is most widely used in acidic foods such as salad dressings (i.e. acetic acid in vinegar), carbonated drinks (carbonic acid), jams and fruit juices (citric acid), pickles (acetic acid), condiments, and frogurt toppings. It is also used as a preservative in medicines and cosmetics. Under these conditions it is converted into benzoic acid (E210), which is bacteriostatic and fungistatic. Benzoic acid is generally not used directly due to its poor water solubility. Concentration as a food preservative is limited by the FDA in the U.S. to 0.1% by weight. Sodium benzoate is also allowed as an animal food additive at up to 0.1%, per the Association of American Feed Control Officials. Sodium benzoate has been replaced by potassium sorbate in the majority of soft drinks in the United Kingdom.

Pharmaceutical applications
Sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amino acids. This leads to excretion of these amino acids and a decrease in ammonia levels. Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia.Total Positive and Negative Syndrome Scale scores dropped by 21% compared to placebo.

Sodium benzoate, along with phenylbutyrate, is used to treat hyperammonemia.

Sodium benzoate, along with caffeine, is used to treat postdural puncture headache, respiratory depression associated with overdosage of narcoticsand with ergotamine to treat vascular headache.

Other uses
Sodium benzoate is also used in fireworks as a fuel in whistle mix, a powder that emits a whistling noise when compressed into a tube and ignited.

Mechanism of food preservation
The mechanism starts with the absorption of benzoic acid into the cell. If the intracellular pH falls to 5 or lower, the anaerobic fermentation of glucose through phosphofructokinase decreases sharply, which inhibits the growth and survival of microorganisms that cause food spoilage.

Health and safety
In the United States, sodium benzoate is designated as generally recognized as safe (GRAS) by the Food and Drug Administration. The International Programme on Chemical Safety found no adverse effects in humans at doses of 647–825 mg/kg of body weight per day.

Cats have a significantly lower tolerance against benzoic acid and its salts than rats and mice.

The human body rapidly clears sodium benzoate by combining it with glycine to form hippuric acid which is then excreted. The metabolic pathway for this begins with the conversion of benzoate by butyrate-CoA ligase into an intermediate product, benzoyl-CoA, which is then metabolized by glycine N-acyltransferase into hippuric acid.

Association with benzene in soft drinks

In combination with ascorbic acid (vitamin C, E300), sodium benzoate and potassium benzoate may form benzene. In 2006, the Food and Drug Administration tested 100 beverages available in the United States that contained both ascorbic acid and benzoate. Four had benzene levels that were above the 5 ppb Maximum Contaminant Level set by the Environmental Protection Agency for drinking water. Most of the beverages that tested above the limit have been reformulated and subsequently tested below the safety limit. Heat, light and shelf life can increase the rate at which benzene is formed.

Information On Sodium Benzoate From PubChem

Sodium benzoate is an organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion. It has a role as an antimicrobial food preservative, a drug allergen, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor, an EC 3.1.1.3 (triacylglycerol lipase) inhibitor, an algal metabolite, a human xenobiotic metabolite and a plant metabolite. It contains a benzoate.

The sodium salt of BENZOIC ACID. It is used as an antifungal preservative in pharmaceutical preparations and foods. It may also be used as a test for liver function.

Sodium Benzoate Powder Lab Features:

• Reagent
• Chemical precursor
• Antiseptic

• Synthesis of dyes
• Inhibition of rust and mildew

Please contact Lab Alley to request a Safety Data Sheet (SDS) and Certificate of Analysis (COA) for Sodium Benzoate Powder.